Title:
PROPELLANT MIXTURES AND AEROSOLS FOR MICRONISING MEDICAMENTS WITH COMPRESSED GAS
Document Type and Number:
WIPO Patent Application WO1997040824
Kind Code:
A3
Abstract:
Propellant mixtures and medicament aerosols which contain them are described for micronizing medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25° C. and a vapor pressure of 20 bars or more at 25° C., and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25° C. and a vapor pressure of 10 bars or less at 25° C. By using this propellant mixture in a medicament aerosol, micronized medicaments are obtained in which approximately 80% by weight of the generated particles have less than 8 mum diameter.
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Inventors:
ZHANG ZHENGFENG (DE)
KNOCH MARTIN (DE)
KNOCH MARTIN (DE)
Application Number:
PCT/EP1997/002149
Publication Date:
December 24, 1997
Filing Date:
April 25, 1997
Export Citation:
Assignee:
PARI GMBH (DE)
ZHANG ZHENGFENG (DE)
KNOCH MARTIN (DE)
ZHANG ZHENGFENG (DE)
KNOCH MARTIN (DE)
International Classes:
A61K9/00; A61K9/12; A61K9/72; A61K31/135; A61K31/35; A61K31/573; A61K31/58; (IPC1-7): A61K9/72
Foreign References:
| US4466838A | 1984-08-21 | |||
| DE2741882A1 | 1978-03-16 | |||
| DE3134723A1 | 1982-04-01 | |||
| US5182097A | 1993-01-26 | |||
| EP0677332A2 | 1995-10-18 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 095, no. 011 26 December 1995 (1995-12-26)
PATENT ABSTRACTS OF JAPAN vol. 011, no. 214 (C - 434) 10 July 1987 (1987-07-10)
PATENT ABSTRACTS OF JAPAN vol. 011, no. 214 (C - 434) 10 July 1987 (1987-07-10)
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