Title:
PROPENYLAMINE DERIVATIVES AND DRUG CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/1983/002113
Kind Code:
A1
Abstract:
Propenylamine derivatives represented by the following general formula:$(8,)$ ADwherein R1 and R2 may be the same or different and each represents hydrogen, alkyl, alkenyl, cycloalkyl, aryl or aralkyl or, when taken together, R1 and R2 represent a hetero ring together with the adjacent nitrogen atom, R3 represents hydrogen, halogen, alkyl or alkoxy, A and B may be the same or different and each represents hydrogen atom or aryl, Z represents oxygen or sulfur atom, q represents alkylene or a group represented by -(CH2)nX1-(CH2)m- (wherein X1 represents oxygen atom or sulfur atom, n represents an integer of 1 to 3, and m represents an integer of 2 to 4), R4 represents H,$(4,)$(wherein R5 represents H, alkyl, alkenyl, alkynyl, alkoxyalkyl, cycloalkyl, aryl or aralkyl, and E represents oxygen or sulfur atom, =NR6 (wherein R6 represents H, cyano, nitro, alkyl, aryl, alkylsulfonyl or arylsulfonyl) or =CHR7 (wherein R7 represents nitro, alkylsulfonyl or arylsulfonyl) or a group represented by the following formula:$(8,)$(wherein X2 represents oxygen atom or sulfur atom, Y represents aryl or pyridyl optionally substituted by one to five lower alkyl or lower alkoxy substituents in arbitrary positions, R8 represents H or alkyl, and p represents 0 or an integer of 1 to 5), with said aryl and aralkyl being optionally substituted in an arbitrary position of the aromatic nucleus by at least one subtituent selected from among halogen, alkyl, alkoxy, trifluoromethyl, and methylenedioxy BD, and pharmaceutically acceptable acid addition salts thereof. These are useful as drugs for digestive organs, drugs for circulatory organs, analgesics, antiinflammatory agents, or intermediates for synthesizing them.
Inventors:
YUKI HIROSHI (JP)
HAMASAKI TOSHIO (JP)
KAWASAKI KAZUYUKI (JP)
NAKANISHI AKIRA (JP)
HAGA KEICHIRO (JP)
HAMASAKI TOSHIO (JP)
KAWASAKI KAZUYUKI (JP)
NAKANISHI AKIRA (JP)
HAGA KEICHIRO (JP)
Application Number:
PCT/JP1981/000392
Publication Date:
June 23, 1983
Filing Date:
December 17, 1981
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
International Classes:
C07D307/38; C07D307/42; C07D307/52; C07D307/56; C07D307/58; (IPC1-7): C07D307/52; A61K31/34; A61K31/44; A61K31/505; C07D307/58; C07D405/12; C07D405/14; C07D409/12; C07D409/14
Foreign References:
| JPS56169685A | 1981-12-26 | |||
| JPS5547670A | 1980-04-04 | |||
| JPS54109963A | 1979-08-29 | |||
| JPS5318557A | 1978-02-20 | |||
| JPS55113776A | 1980-09-02 | |||
| JPS54115385A | 1979-09-07 |
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