Title:
PROPHYLACTIC AGENT FOR SQUAMOUS CARCINOMA, SQUAMOUS CARCINOMA MODEL ANIMAL, AND METHOD FOR PRODUCING SAID MODEL ANIMAL
Document Type and Number:
WIPO Patent Application WO/2013/099939
Kind Code:
A1
Abstract:
Provided are: a fermented material which is effective for the prevention of squamous carcinoma that is developed by Candida infection; a model animal for squamous carcinoma that is developed by Candida infection, in which the difference among individuals is smaller than those in conventional model animals and pharmacological efficacy can be evaluated more properly; and a method for producing the model animal.
A prophylactic agent for squamous carcinoma that is developed by Candida infection, which comprises a fermented material produced by fermenting milk with L. bulgaricus, S. thermophilus and L. gasseri as an active ingredient.
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Inventors:
OZAKI KIYOKAZU (JP)
UCHIDA MASAYUKI (JP)
MATSUURA TETSURO (JP)
UCHIDA MASAYUKI (JP)
MATSUURA TETSURO (JP)
Application Number:
PCT/JP2012/083643
Publication Date:
July 04, 2013
Filing Date:
December 26, 2012
Export Citation:
Assignee:
MEIJI CO LTD (JP)
JOSHO GAKUEN EDUCATIONAL FOUNDATION (JP)
JOSHO GAKUEN EDUCATIONAL FOUNDATION (JP)
International Classes:
A23C9/12; A01K67/027; A23C9/127; A23L1/00; A23L1/30; A61K35/74; A61P35/00; G01N33/15; G01N33/50
Other References:
ISHIDA,H. ET AL.: "Milk fermented with yogurt cultures and Lactobacillus gasseri SBT2055 (LG2055: strain Yukijirushi) compared with yogurt: Influence on intestinal microflora and bowel habits of healthy young women", PHARMACOMETRICS, vol. 61, no. 2/3, 2001, pages 203 - 213
AWAISHEH,S.S. ET AL.: "Incorporation of selected nutraceuticals and probiotic bacteria into a fermented milk", INT.DAIRY J., vol. 15, no. 11, November 2005 (2005-11-01), pages 1184 - 1190, XP004970567
TOMOYA SANO ET AL.: "Effects of antifungal agent, itraconazole, on proliferative changes of forestomach in alloxan-induced diabetic rats", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 2009, pages 129
SANO,T. ET AL.: "Effects of the antifungal agent itraconazole on proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats", TOXICOL.PATHOLOGY, vol. 37, 2009, pages 790 - 798, XP055076851
WILLIAMS,D.W. ET AL.: "Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change", GERODONTOLOGY, vol. 18, no. 2, December 2001 (2001-12-01), pages 73 - 78, XP055076860
AWAISHEH,S.S. ET AL.: "Incorporation of selected nutraceuticals and probiotic bacteria into a fermented milk", INT.DAIRY J., vol. 15, no. 11, November 2005 (2005-11-01), pages 1184 - 1190, XP004970567
TOMOYA SANO ET AL.: "Effects of antifungal agent, itraconazole, on proliferative changes of forestomach in alloxan-induced diabetic rats", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 2009, pages 129
SANO,T. ET AL.: "Effects of the antifungal agent itraconazole on proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats", TOXICOL.PATHOLOGY, vol. 37, 2009, pages 790 - 798, XP055076851
WILLIAMS,D.W. ET AL.: "Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change", GERODONTOLOGY, vol. 18, no. 2, December 2001 (2001-12-01), pages 73 - 78, XP055076860
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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