Title:
PROPHYLACTIC OR PREVENTIVE AGENT, ANTIBACTERIAL AGENT, AND ORAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/057898
Kind Code:
A1
Abstract:
[Problem] To provide an antibacterial agent that is highly safe and inhibits, at a low concentration, the growth of oral bacteria such as Porphyromonas gingivalis causative of various diseases. [Solution] By using honeydew honey as an active ingredient, a composition, which efficiently inhibits the growth of oral bacteria such as Porphyromonas gingivalis and prevents or treats diseases caused by the oral bacteria such as periodontal disease, tooth decay, halitosis, dementia, diabetes and arteriosclerosis, has been found.
Inventors:
OHSHIRO HIDEO (JP)
NAKAJIMA HIROSHI (JP)
MUKAI KATSUYUKI (JP)
NAKAJIMA HIROSHI (JP)
MUKAI KATSUYUKI (JP)
Application Number:
PCT/JP2023/031000
Publication Date:
March 21, 2024
Filing Date:
August 28, 2023
Export Citation:
Assignee:
INST OF ORIENTAL MEDICAL SCIENCE CO LTD (JP)
International Classes:
A61K35/644; A23L33/10; A61K8/9767; A61K36/15; A61P1/02; A61P3/10; A61P9/10; A61P25/28; A61Q11/00
Foreign References:
| US20170072024A1 | 2017-03-16 |
Other References:
BUCEKOVA MARCELA, BURIOVA MONIKA, PEKARIK LADISLAV, MAJTAN VIKTOR, MAJTAN JURAJ: "Phytochemicals-mediated production of hydrogen peroxide is crucial for high antibacterial activity of honeydew honey", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, 13 June 2018 (2018-06-13), US , pages 9061, XP093146280, ISSN: 2045-2322, DOI: 10.1038/s41598-018-27449-3
BOGDANOV S: "Nature and origin of the antibacterial substances in honey", LWT- FOOD SCIENCE AND TECHNOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 30, no. 7, 1 January 1997 (1997-01-01), United Kingdom , pages 748 - 753, XP003018432, ISSN: 0023-6438, DOI: 10.1006/fstl.1997.0259
DINKOV DINKO: "The antibacterial activity of acacia, multifloral and oak honeydew honeys", INTERNATIONAL JOURNAL OF VETERINARY SCIENCES AND ANIMAL HUSBANDRY, vol. 1, no. 2, 1 January 2016 (2016-01-01), pages 7 - 10, XP093146287, ISSN: 2456-2912
NODA MITSUHIRO, MASATSUGU YAMAMURA, ICHIO TAKASE, SHOJIRO ASAI, TOSHIHIKO UMEMOTO, ISAMU NAMIKAWA: "Characteristics of Staphylococcus aureus isolated from the oral and nasal cavities of healthy young adults", JPN. J. ORAL BIOL, vol. 36, 1 January 1994 (1994-01-01), pages 263 - 273, XP093146289
BOGDANOV S: "Nature and origin of the antibacterial substances in honey", LWT- FOOD SCIENCE AND TECHNOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 30, no. 7, 1 January 1997 (1997-01-01), United Kingdom , pages 748 - 753, XP003018432, ISSN: 0023-6438, DOI: 10.1006/fstl.1997.0259
DINKOV DINKO: "The antibacterial activity of acacia, multifloral and oak honeydew honeys", INTERNATIONAL JOURNAL OF VETERINARY SCIENCES AND ANIMAL HUSBANDRY, vol. 1, no. 2, 1 January 2016 (2016-01-01), pages 7 - 10, XP093146287, ISSN: 2456-2912
NODA MITSUHIRO, MASATSUGU YAMAMURA, ICHIO TAKASE, SHOJIRO ASAI, TOSHIHIKO UMEMOTO, ISAMU NAMIKAWA: "Characteristics of Staphylococcus aureus isolated from the oral and nasal cavities of healthy young adults", JPN. J. ORAL BIOL, vol. 36, 1 January 1994 (1994-01-01), pages 263 - 273, XP093146289
Attorney, Agent or Firm:
IDO Atsushi (JP)
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