Title:
PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DISEASES ACCOMPANIED BY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2020/145231
Kind Code:
A1
Abstract:
Provided is a prophylactic and/or therapeutic agent for diseases accompanied by fibrosis. The present invention provides: a medicinal composition for preventing and/or treating diseases accompanied by organ and/or tissue fibrosis, the composition comprising a cell mixture and/or a cell aggregate that includes mesenchymal cells and endothelial cells (hepatocytes may be further included); and an inhibitor for inhibiting organ and/or tissue fibrosis, the inhibitor comprising both mesenchymal cells and endothelial cells or a cell aggregate thereof. A cell mixture and/or a cell aggregate that includes mesenchymal cells and endothelial cells (hepatocytes may be further included) is transplanted to a subject, so that an expression of fibrinolysins such as MMP1 and MMP13 (fibrinolytic system factors) increases and can inhibit organ and/or tissue fibrosis, thereby preventing and/or treating diseases accompanied by organ and/or tissue fibrosis.
Inventors:
TANIGUCHI HIDEKI (JP)
MURATA SOICHIRO (JP)
MURATA SOICHIRO (JP)
Application Number:
PCT/JP2020/000043
Publication Date:
July 16, 2020
Filing Date:
January 06, 2020
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
International Classes:
A61P3/00; A61K35/407; A61K35/44; A61K35/545; A61L27/38
Domestic Patent References:
| WO2013047639A1 | 2013-04-04 | |||
| WO2015012158A1 | 2015-01-29 |
Foreign References:
| JP2016209303A | 2016-12-15 |
Other References:
MURATA, SOICHIRO: "Development of new therapy for liver cirrhosis using human iPS cells (section "outline of research achievements")", KAKEN PROJECT, 17 December 2018 (2018-12-17), Retrieved from the Internet
TAKEBE, TAKANORI ET AL.: "Current status for regenerative medicine for liver diseases", JAPANESE JOURNAL OF PEDIATRIC MEDICINE, vol. 49, no. 7, 14 July 2017 (2017-07-14), pages 981 - 986
TAKEBE, TAKANORI ET AL.: "Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells", CELL REPORT, vol. 21, no. 10, 1 December 2017 (2017-12-01), pages 2661 - 2670, XP055602129, DOI: 10.1016/j.celrep.2017.11.005
TAKEBE, TAKANORI ET AL.: "Current status for regenerative medicine for liver diseases", JAPANESE JOURNAL OF PEDIATRIC MEDICINE, vol. 49, no. 7, 14 July 2017 (2017-07-14), pages 981 - 986
TAKEBE, TAKANORI ET AL.: "Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells", CELL REPORT, vol. 21, no. 10, 1 December 2017 (2017-12-01), pages 2661 - 2670, XP055602129, DOI: 10.1016/j.celrep.2017.11.005
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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