Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR HEPATIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2013/162021
Kind Code:
A1
Abstract:
The present invention provides: a prophylactic or therapeutic agent for hepatic diseases, which comprises an AIM, a partial peptide of the AIM, or a nucleic acid comprising a nucleotide sequence encoding the AIM or the partial peptide; a method for screening for a prophylactic or therapeutic agent for hepatic diseases using an animal that is produced by feeding a high-fat diet to a non-human mammal with insufficient expression of an AIM; and others.
Inventors:
MIYAZAKI TORU (JP)
Application Number:
PCT/JP2013/062469
Publication Date:
October 31, 2013
Filing Date:
April 26, 2013
Export Citation:
Assignee:
MIYAZAKI TORU (JP)
DAINIPPON SUMITOMO PHARMA CO (JP)
DAINIPPON SUMITOMO PHARMA CO (JP)
International Classes:
A61K38/00; A61K31/713; A61K45/00; A61P1/16; A61P35/00; C12N15/09; G01N33/15; G01N33/50; G01N33/68; C12Q1/68
Domestic Patent References:
| WO2011145723A1 | 2011-11-24 |
Other References:
MIYAZAKI T. ET AL.: "Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily", J.EXP.MED., vol. 189, 1999, pages 413 - 422, XP008149323
TORU MIYAZAKI: "Apoptosis Yokusei Inshi AIM no Kino Seigyo ni yoru Domyaku Koka no Atarashii Chiryoho Kaihatsu o Mezashite", THER.RES., vol. 29, 2008, pages 144 - 151, XP008167256
STEPANOVA M. ET AL.: "Protein pathway biomarker signature associated with superimposed non-alcoholic steatohepatitis(NASH) and advanced fibrosis in patients with chronic hapatitis C", J.HEPATOL., vol. 52, no. SUPPL., 2010, pages S157, XP026998281
LU Y. ET AL.: "Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma", BMC GASTROENTEROL., vol. 10, 2010, pages 115, XP021074039
J EXP MED, vol. 189, 1999, pages 413 - 422
J BIOL CHEM, vol. 276, 2001, pages 22910 - 22914
AM J PATHOL, vol. 162, 2003, pages 837 - 847
CELL METAB, vol. 1, 2005, pages 201 - 213
CELL METAB, vol. 11, 2010, pages 479 - 492
PNAS, vol. 108, 2011, pages 12072 - 12077
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERS; MILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
M. BODANSZKY; M.A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER; LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
J. SAMBROOK ET AL.: "Molecular Cloning, 2nd ed.", 1989, COLD SPRING HARBOR LAB. PRESS
PROC. NATL. ACAD. SCI. USA, vol. 60, 1968, pages 160
NUCLEIC ACIDS RESEARCH, vol. 9, 1981, pages 309
JOURNAL OF MOLECULAR BIOLOGY, vol. 120, 1978, pages 517
JOURNAL OF MOLECULAR BIOLOGY, vol. 41, 1969, pages 459
GENETICS, vol. 39, 1954, pages 440
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
GENE, vol. 17, 1982, pages 107
"Shin Saibo Kogaku Jikken Protocol (New Cell Engineering Experimental Protocol)", vol. 8, 1995, SHUJUNSHA, article "Saibo Kogaku (Cell Engineering)", pages: 263 - 267
VIROLOGY, vol. 52, 1973, pages 456
MILLER: "Journal of Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY, pages: 431 - 433
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
MIYAZAKI T. ET AL., J. EXP. MED., vol. 189, 1999, pages 413 - 422
EVANS; KAUFMAN, NATURE, vol. 292, 1981, pages 154
M.J. EVANS; M.H. KAUFMAN, NATURE, vol. 292, 1981, pages 154
G.R. MARTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 78, 1981, pages 7634
T. C. DOETSCHMAN ET AL., JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, vol. 87, 1985, pages 27
PROC. NATL. ACAD. SCI. USA, vol. 99, no. 4, 2002, pages 2140 - 2145
PROC. NATL. ACAD. SCI. USA, vol. 98, no. 10, 2001, pages 5572 - 5577
NUCLEIC ACIDS RES., vol. 29, no. 13, 2001, pages 2780 - 2788
NATURE, vol. 411, no. 6836, 2001, pages 494 - 498
PROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 13090 - 13095
HIROSHI IRIE: "Radioimmunoassay", 1974, KODANSHA LTD.
HIROSHI IRIE: "Sequel to the Radioimmunoassay", 1979, KODANSHA LTD.
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1978, IGAKUSHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 2nd ed.", 1982, IGAKUSHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1987, IGAKUSHOIN
"Methods in ENZYMOLOGY", vol. 70, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 73, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 74, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 84, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 92, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 121, ACADEMIC PRESS
TORU MIYAZAKI: "Apoptosis Yokusei Inshi AIM no Kino Seigyo ni yoru Domyaku Koka no Atarashii Chiryoho Kaihatsu o Mezashite", THER.RES., vol. 29, 2008, pages 144 - 151, XP008167256
STEPANOVA M. ET AL.: "Protein pathway biomarker signature associated with superimposed non-alcoholic steatohepatitis(NASH) and advanced fibrosis in patients with chronic hapatitis C", J.HEPATOL., vol. 52, no. SUPPL., 2010, pages S157, XP026998281
LU Y. ET AL.: "Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma", BMC GASTROENTEROL., vol. 10, 2010, pages 115, XP021074039
J EXP MED, vol. 189, 1999, pages 413 - 422
J BIOL CHEM, vol. 276, 2001, pages 22910 - 22914
AM J PATHOL, vol. 162, 2003, pages 837 - 847
CELL METAB, vol. 1, 2005, pages 201 - 213
CELL METAB, vol. 11, 2010, pages 479 - 492
PNAS, vol. 108, 2011, pages 12072 - 12077
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERS; MILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
M. BODANSZKY; M.A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER; LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
J. SAMBROOK ET AL.: "Molecular Cloning, 2nd ed.", 1989, COLD SPRING HARBOR LAB. PRESS
PROC. NATL. ACAD. SCI. USA, vol. 60, 1968, pages 160
NUCLEIC ACIDS RESEARCH, vol. 9, 1981, pages 309
JOURNAL OF MOLECULAR BIOLOGY, vol. 120, 1978, pages 517
JOURNAL OF MOLECULAR BIOLOGY, vol. 41, 1969, pages 459
GENETICS, vol. 39, 1954, pages 440
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
GENE, vol. 17, 1982, pages 107
"Shin Saibo Kogaku Jikken Protocol (New Cell Engineering Experimental Protocol)", vol. 8, 1995, SHUJUNSHA, article "Saibo Kogaku (Cell Engineering)", pages: 263 - 267
VIROLOGY, vol. 52, 1973, pages 456
MILLER: "Journal of Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY, pages: 431 - 433
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1
MIYAZAKI T. ET AL., J. EXP. MED., vol. 189, 1999, pages 413 - 422
EVANS; KAUFMAN, NATURE, vol. 292, 1981, pages 154
M.J. EVANS; M.H. KAUFMAN, NATURE, vol. 292, 1981, pages 154
G.R. MARTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 78, 1981, pages 7634
T. C. DOETSCHMAN ET AL., JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, vol. 87, 1985, pages 27
PROC. NATL. ACAD. SCI. USA, vol. 99, no. 4, 2002, pages 2140 - 2145
PROC. NATL. ACAD. SCI. USA, vol. 98, no. 10, 2001, pages 5572 - 5577
NUCLEIC ACIDS RES., vol. 29, no. 13, 2001, pages 2780 - 2788
NATURE, vol. 411, no. 6836, 2001, pages 494 - 498
PROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 13090 - 13095
HIROSHI IRIE: "Radioimmunoassay", 1974, KODANSHA LTD.
HIROSHI IRIE: "Sequel to the Radioimmunoassay", 1979, KODANSHA LTD.
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1978, IGAKUSHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay, 2nd ed.", 1982, IGAKUSHOIN
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1987, IGAKUSHOIN
"Methods in ENZYMOLOGY", vol. 70, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 73, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 74, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 84, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 92, ACADEMIC PRESS
"METHODS IN ENZYMOLOGY", vol. 121, ACADEMIC PRESS
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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