Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR PERIOSTIN-MEDIATED DISEASE AND PRURITUS ASSOCIATED THEREWITH
Document Type and Number:
WIPO Patent Application WO/2024/024915
Kind Code:
A1
Abstract:
Provided is a technique for preventing or treating a periostin-mediated disease and pruritus associated with the disease.
The present invention relates to, for example, a prophylactic or therapeutic agent for a periostin-mediated disease or pruritus associated with the disease, said agent containing a specific periostin receptor antagonist as an active ingredient.
Inventors:
IZUHARA KENJI (JP)
NUNOMURA SATOSHI (JP)
NANRI YASUHIRO (JP)
KITAJIMA ISAO (JP)
UTA DAISUKE (JP)
NUNOMURA SATOSHI (JP)
NANRI YASUHIRO (JP)
KITAJIMA ISAO (JP)
UTA DAISUKE (JP)
Application Number:
PCT/JP2023/027657
Publication Date:
February 01, 2024
Filing Date:
July 27, 2023
Export Citation:
Assignee:
UNIV SAGA (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
International Classes:
A61K31/506; A61P17/04; A61P29/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2021055713A1 | 2021-03-25 | |||
| WO2001054726A1 | 2001-08-02 | |||
| WO2014122228A1 | 2014-08-14 |
Foreign References:
| JP2006036712A | 2006-02-09 |
Other References:
KUBOTA, D. ; ISHIKAWA, M. ; YAMAMOTO, M. ; MURAKAMI, S. ; HACHISU, M. ; KATANO, K. ; AJITO, K.: "Tricyclic pharmacophore-based molecules as novel integrin avB3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting avB3/aIIbB3 dual antagonistic activity", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 7, 1 April 2006 (2006-04-01), AMSTERDAM, NL, pages 2089 - 2108, XP027992471, ISSN: 0968-0896
ISHIKAWA, M. ; KUBOTA, D. ; YAMAMOTO, M. ; KURODA, C. ; IGUCHI, M. ; KOYANAGI, A. ; MURAKAMI, S. ; AJITO, K.: "Tricyclic pharmacophore-based molecules as novel integrin avB3 antagonists. Part 2: Synthesis of potent avB3/aIIbB3 dual antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 7, 1 April 2006 (2006-04-01), AMSTERDAM, NL, pages 2109 - 2130, XP027992472, ISSN: 0968-0896
ISHIKAWA, M. ; HIRAIWA, Y. ; KUBOTA, D. ; TSUSHIMA, M. ; WATANABE, T. ; MURAKAMI, S. ; OUCHI, S. ; AJITO, K.: "Tricyclic pharmacophore-based molecules as novel integrin avB3 antagonists. Part III: Synthesis of potent antagonists with avB3/aIIbB3 dual activity and improved water solubility", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 7, 1 April 2006 (2006-04-01), AMSTERDAM, NL, pages 2131 - 2150, XP027992473, ISSN: 0968-0896
ZHOU XIAOYAN, ZHANG JI, HAIMBACH ROBIN, ZHU WEI, MAYER-EZELL ROSEMARY, GARCIA-CALVO MARGARITA, SMITH ELIZABETH, PRICE OLGA, KAN YA: "An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model", PHARMACOLOGY RESEARCH & PERSPECTIVES, JOHN WILEY & SONS LTD., GB, vol. 5, no. 5, 1 October 2017 (2017-10-01), GB , pages 1 - 14, XP055976571, ISSN: 2052-1707, DOI: 10.1002/prp2.354
ISHIKAWA, M. ; KUBOTA, D. ; YAMAMOTO, M. ; KURODA, C. ; IGUCHI, M. ; KOYANAGI, A. ; MURAKAMI, S. ; AJITO, K.: "Tricyclic pharmacophore-based molecules as novel integrin avB3 antagonists. Part 2: Synthesis of potent avB3/aIIbB3 dual antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 7, 1 April 2006 (2006-04-01), AMSTERDAM, NL, pages 2109 - 2130, XP027992472, ISSN: 0968-0896
ISHIKAWA, M. ; HIRAIWA, Y. ; KUBOTA, D. ; TSUSHIMA, M. ; WATANABE, T. ; MURAKAMI, S. ; OUCHI, S. ; AJITO, K.: "Tricyclic pharmacophore-based molecules as novel integrin avB3 antagonists. Part III: Synthesis of potent antagonists with avB3/aIIbB3 dual activity and improved water solubility", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 7, 1 April 2006 (2006-04-01), AMSTERDAM, NL, pages 2131 - 2150, XP027992473, ISSN: 0968-0896
ZHOU XIAOYAN, ZHANG JI, HAIMBACH ROBIN, ZHU WEI, MAYER-EZELL ROSEMARY, GARCIA-CALVO MARGARITA, SMITH ELIZABETH, PRICE OLGA, KAN YA: "An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model", PHARMACOLOGY RESEARCH & PERSPECTIVES, JOHN WILEY & SONS LTD., GB, vol. 5, no. 5, 1 October 2017 (2017-10-01), GB , pages 1 - 14, XP055976571, ISSN: 2052-1707, DOI: 10.1002/prp2.354
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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