Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS OR RHEUMATOID ARTHRITIS-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2010/101192
Kind Code:
A1
Abstract:
Disclosed is a prophylactic or therapeutic agent for rheumatoid arthritis or diseases caused by rheumatoid arthritis (rheumatoid arthritis-related diseases), which comprises HLA-G or a dimer thereof as an active ingredient. As the HLA-G, the following protein (a) or (b) can be used suitably.
(a) A protein which comprises the amino acid sequence depicted in SEQ ID NO:1.
(b) A protein which comprises an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues other than the amino acid residue located on Position-42 in the amino acid sequence depicted in SEQ ID NO:1 and which has a binding activity to a leukocyte Ig-like receptor and/or CD8.
Inventors:
MAENAKA KATSUMI (JP)
KUROKI KIMIKO (JP)
OHDO SHIGEHIRO (JP)
KOYANAGI SATORU (JP)
KUROKI KIMIKO (JP)
OHDO SHIGEHIRO (JP)
KOYANAGI SATORU (JP)
Application Number:
PCT/JP2010/053459
Publication Date:
September 10, 2010
Filing Date:
March 03, 2010
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
MAENAKA KATSUMI (JP)
KUROKI KIMIKO (JP)
OHDO SHIGEHIRO (JP)
KOYANAGI SATORU (JP)
MAENAKA KATSUMI (JP)
KUROKI KIMIKO (JP)
OHDO SHIGEHIRO (JP)
KOYANAGI SATORU (JP)
International Classes:
A61K38/00; A61P19/00; A61P19/02; A61P43/00; C07K14/74; C12N15/09
Domestic Patent References:
| WO2007011044A1 | 2007-01-25 | |||
| WO2007011044A1 | 2007-01-25 |
Foreign References:
| JP2005532256A | 2005-10-27 |
Other References:
VERBRUGGEN, L.A. ET AL.: "Soluble HLA-G in rheumatoid arthritis", HUM IMMUNOL, vol. 67, no. 8, 2006, pages 561 - 567, XP024993609
MENIER, C. ET AL.: "The HLA-G non classical MHC class I molecule is expressed in cancer with poor prognosis. Implications in tumour escape from immune system and clinical applications", ATLAS GENET CYTOGENET ONCOL HAEMATOL, July 2008 (2008-07-01), Retrieved from the Internet [retrieved on 20100401]
See also references of EP 2404610A4
M. SHIROISHI ET AL., PROC. NATL. ACAD. SCI. USA., NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 15, 2003, pages 8856 - 8861
M. SHIROISHI ET AL.: "Journal of Biological Chemistry", vol. 281, 2006, THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC., pages: 10439 - 10447
J. LEMAOULT ET AL., TISSUE ANTIGENS, vol. 62, 2003, pages 273 - 84
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SHIROISHI ET AL., PROC. NATL. ACAD. SCI., USA, 2003
M. SHIROISHI ET AL., PROC. NATL. ACAD. SCI., U S A, vol. 100, 2003, pages 8856 - 61
C.S. CLEMEMS ET AL., PROC. NATL. ACAD. SCI., 2005
MENIER, C. ET AL.: "The HLA-G non classical MHC class I molecule is expressed in cancer with poor prognosis. Implications in tumour escape from immune system and clinical applications", ATLAS GENET CYTOGENET ONCOL HAEMATOL, July 2008 (2008-07-01), Retrieved from the Internet
See also references of EP 2404610A4
M. SHIROISHI ET AL., PROC. NATL. ACAD. SCI. USA., NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 15, 2003, pages 8856 - 8861
M. SHIROISHI ET AL.: "Journal of Biological Chemistry", vol. 281, 2006, THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC., pages: 10439 - 10447
J. LEMAOULT ET AL., TISSUE ANTIGENS, vol. 62, 2003, pages 273 - 84
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SHIROISHI ET AL., PROC. NATL. ACAD. SCI., USA, 2003
M. SHIROISHI ET AL., PROC. NATL. ACAD. SCI., U S A, vol. 100, 2003, pages 8856 - 61
C.S. CLEMEMS ET AL., PROC. NATL. ACAD. SCI., 2005
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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