Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR STEATOHEPATITIS OR FATTY LIVER
Document Type and Number:
WIPO Patent Application WO/2006/135084
Kind Code:
A1
Abstract:
Disclosed are a pharmaceutical for the prevention or treatment of steatohepatitis, particularly non-alcoholic steatohepatitis or fatty liver and a beverage/food for the prevention or amelioration of the disease. A prophylactic or therapeutic agent for steatohepatitis, non-alcoholic steatohepatitis or fatty liver comprising luteolin and/or a glucoside thereof; and a beverage/food for the prevention or amelioration of steatohepatitis, non-alcoholic steatohepatitis or fatty liver comprising luteolin and/or a glucoside thereof, preferably the beverage/food having a label on which the words 'this product is intended to be used for the prevention or amelioration of the disease' are described.
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Inventors:
KOGA HIRONORI (JP)
Application Number:
PCT/JP2006/312209
Publication Date:
December 21, 2006
Filing Date:
June 13, 2006
Export Citation:
Assignee:
UNIV KURUME (JP)
KOGA HIRONORI (JP)
KOGA HIRONORI (JP)
International Classes:
C07D311/30; A23L1/30; A61K31/352; A61K31/7048; A61P1/16; A61P3/06; C07H15/203; C07H17/07
Domestic Patent References:
| WO2002062365A1 | 2002-08-15 |
Foreign References:
| JPS6442427A | 1989-02-14 | |||
| CN1589804A | 2005-03-09 | |||
| JPH09143070A | 1997-06-03 | |||
| JPH0761927A | 1995-03-07 | |||
| JP2002010753A | 2002-01-15 | |||
| JPH09194390A | 1997-07-29 | |||
| JP2005350472A | 2005-12-22 |
Other References:
TSUTSUMI K. ET AL.: "Water extract of defatted rice bran suppresses visceral fat accumulation in rats", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 48, no. 5, 2000, pages 1653 - 1656, XP003003004
GUILLET-DENIAU I. ET AL.: "Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway", JOURNAL OF CELL SCIENCE, vol. 117, no. 10, 2004, pages 1937 - 1944, XP003003005
SELVENDIRAN K. ET AL.: "A ubiquitin-dependent degradation of signal transducer and activator of transcription (STAT) 3 is promoted in luteolin-induced apoptosis in human hepatoma cells", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 46, 2005, pages 722 - 723, XP003003006
JANSEN P.L.M.: "Nonalcoholic steatohepatitis", THE NETHERLANDS JOURNAL OF MEDICINE, vol. 62, no. 7, 2004, pages 217 - 224, XP003003007
GUILLET-DENIAU I. ET AL.: "Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway", JOURNAL OF CELL SCIENCE, vol. 117, no. 10, 2004, pages 1937 - 1944, XP003003005
SELVENDIRAN K. ET AL.: "A ubiquitin-dependent degradation of signal transducer and activator of transcription (STAT) 3 is promoted in luteolin-induced apoptosis in human hepatoma cells", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 46, 2005, pages 722 - 723, XP003003006
JANSEN P.L.M.: "Nonalcoholic steatohepatitis", THE NETHERLANDS JOURNAL OF MEDICINE, vol. 62, no. 7, 2004, pages 217 - 224, XP003003007
Attorney, Agent or Firm:
Takashima, Hajime (Osaka Midosuji Bldg. 1-1, Fushimimachi
4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
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