Title:
PROPHYLACTIC, THERAPEUTIC OR ALLEVIATING AGENT FOR PERIPHERAL NERVE DISORDERS CAUSED BY ANTI-CANCER AGENTS
Document Type and Number:
WIPO Patent Application WO/2014/081029
Kind Code:
A1
Abstract:
The purpose of the present invention is to prevent, treat or alleviate peripheral nerve disorders caused by anti-cancer agents satisfactorily and sustainably. The present invention provides a prophylactic, therapeutic or alleviating agent for peripheral nerve disorders caused by anti-cancer agents, said prophylactic, therapeutic or alleviating agent being intended to be administered non-topically and containing a PKC inhibitor or a MEK/ERK pathway inhibitor as an active ingredient. The present invention also provides a prophylactic, therapeutic or alleviating agent for peripheral nerve disorders caused by anti-cancer agents, said prophylactic, therapeutic or alleviating agent containing a MEK inhibitor or an ERK inhibitor as an active ingredient.
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Inventors:
NISHIDA SHOZO (JP)
TSUBAKI MASANOBU (JP)
OGAWA NAOKI (JP)
SUZUYAMA NAOHIRO (JP)
TANI TADAHUMI (JP)
TSUBAKI MASANOBU (JP)
OGAWA NAOKI (JP)
SUZUYAMA NAOHIRO (JP)
TANI TADAHUMI (JP)
Application Number:
PCT/JP2013/081665
Publication Date:
May 30, 2014
Filing Date:
November 25, 2013
Export Citation:
Assignee:
UNIV KINKI (JP)
International Classes:
A61K45/00; A61K31/138; A61P25/02
Other References:
NORCINI, M. ET AL.: "Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat", PAIN, vol. 146, 2009, pages 141 - 147
JAGGI, AS. ET AL.: "Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats", FOOD CHEM TOXICOL, vol. 50, no. 5, May 2012 (2012-05-01), pages 1295 - 301
"4-Methylcatechol ameliorates chronic pain concurrent with mood disorder by inducing brain -derived neurotrophic factor", THE JOURNAL OF PAIN, vol. 13, no. 4, April 2012 (2012-04-01), pages S39
JAGGI, AS. ET AL.: "Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats", FOOD CHEM TOXICOL, vol. 50, no. 5, May 2012 (2012-05-01), pages 1295 - 301
"4-Methylcatechol ameliorates chronic pain concurrent with mood disorder by inducing brain -derived neurotrophic factor", THE JOURNAL OF PAIN, vol. 13, no. 4, April 2012 (2012-04-01), pages S39
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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