PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF

Title:

PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/201167

Kind Code:

A3

Abstract:

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Inventors:

BIEDIGER RONALD (US)
BENISH MICHELE (US)
HARDY LINDSAY (US)
BOYD VINCENT (US)
MARKET ROBERT (US)
THRASH THOMAS (US)
YOUNG BRANDON (US)

Application Number:

PCT/US2018/039289

Publication Date:

December 20, 2018

Filing Date:

June 25, 2018

Export Citation:

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Assignee:

AVIARA PHARMACEUTICALS INC (US)

International Classes:

C07D213/75; A61K31/435; A61K31/4353; A61K31/4375; A61K31/4412; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/50; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P19/02; A61P25/00; A61P27/02; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D221/04; C07D237/22; C07D401/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D471/00; C07D471/04; C07D495/04

Domestic Patent References:

WO2000067746A1	2000-11-16
WO2000068188A1	2000-11-16

Foreign References:

EP1203766A2	2002-05-08
US6262084B1	2001-07-17

Other References: