Title:
PROPIONIC ACID DERIVATIVES AND THEIR USE AS HPPARS ACTIVATORS
Document Type and Number:
WIPO Patent Application WO2004000762
Kind Code:
A3
Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).
Inventors:
BESWICK PAUL JOHN (GB)
HARLING JOHN DAVID (GB)
KLEANTHOUS SAVVAS (GB)
PATEL VIPULKUMAR KANTIBHAI (GB)
SIMPSON JULIET (GB)
HARLING JOHN DAVID (GB)
KLEANTHOUS SAVVAS (GB)
PATEL VIPULKUMAR KANTIBHAI (GB)
SIMPSON JULIET (GB)
Application Number:
PCT/EP2003/006416
Publication Date:
October 14, 2004
Filing Date:
June 18, 2003
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORP (US)
BESWICK PAUL JOHN (GB)
HARLING JOHN DAVID (GB)
KLEANTHOUS SAVVAS (GB)
PATEL VIPULKUMAR KANTIBHAI (GB)
SIMPSON JULIET (GB)
BESWICK PAUL JOHN (GB)
HARLING JOHN DAVID (GB)
KLEANTHOUS SAVVAS (GB)
PATEL VIPULKUMAR KANTIBHAI (GB)
SIMPSON JULIET (GB)
International Classes:
A61K31/192; A61K31/275; A61K31/44; A61K31/4965; A61K31/505; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P25/00; A61P43/00; C07C217/58; C07C217/80; C07C233/18; C07C233/25; C07C255/50; C07C255/58; C07C311/08; C07C311/29; C07C311/48; C07C323/25; C07C323/47; C07D213/74; C07D239/42; C07D241/20; (IPC1-7): C07C217/58; C07D213/74; C07D213/75; C07D239/42; C07D241/20; C07C311/29; A61K31/33; A61K31/18; A61K31/195
Domestic Patent References:
| WO2002028821A2 | 2002-04-11 | |||
| WO2000023407A2 | 2000-04-27 |
Foreign References:
| FR2273518A1 | 1976-01-02 | |||
| EP1067109A1 | 2001-01-10 | |||
| US3912756A | 1975-10-14 |
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