Title:
PROSTACYCLINES AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/1984/002902
Kind Code:
A1
Abstract:
Novel prostacyclines represented by the formula (I), wherein ---- between 2- and 3-positions represents that the bond between these positions is a single or double bond, G represents -CO2R5 or -CONR6R7, wherein R5 represents H, C1-C10 alkyl, substituted or unsubstituted alicyclic group, substituted or unsubstituted phenyl-(C1-C2) alkyl group, tri(C1-C10)hydrocarbyl-silyl group or an equivalent cation, R6 and R7 are the same or different and each represents H, C1-C10 alkyl or, when combined together, they represent a 5- or 6-membered, substituted or unsubstituted ring together with the adjacent nitrogen atom optionally containing further hetero atom(s), R1 represents H or methyl, R2 represents unsubstituted C3-C8 alkyl, substituted or unsubstituted alicylic group, or substituted C1-C5 alkyl group substituted by optionally substituted phenyl, phenoxy, C1-C6 alkoxy or C5-C6 cycloalkyl, R3 and R4 are the same or different and each represents H, C2-C7 acyl, tri(C1-C7)hydrocarbyl-silyl, or a group forming an acetal bond together with the oxygen atom of OH. The compounds exhibit excellent pharmacological effects such as blood platelet enticoagulating effect, thus being useful as thrombosis-treating agents, arteriosclerosis-treating agents, etc.
Inventors:
IKEGAMI SHIRO (JP)
KUROZUMI SEIZI (JP)
KUROZUMI SEIZI (JP)
Application Number:
PCT/JP1984/000018
Publication Date:
August 02, 1984
Filing Date:
January 26, 1984
Export Citation:
Assignee:
TEIJIN LTD (JP)
International Classes:
A61K31/557; A61P7/02; A61P43/00; C07C51/00; C07C59/46; C07C67/00; C07C69/73; C07C69/732; C07C231/00; C07C231/12; C07C235/30; C07C67/30; C07C405/00; C07D309/12; C07F7/18; (IPC1-7): C07C59/46; C07C59/54; C07C59/56; C07C59/62; C07C59/72; C07C69/732; C07C69/734; C07C103/737; C07C103/76; C07D309/12; C07F7/18
Other References:
Tetrahedron Letters, Vol. 21, No. 2, (1980), (England), MASAKATSU SHIBASAKI and two others, (Total Synthesis of the Carbon Analog of 6-PGI1), p. 169-172
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