PROSTACYCLINS AND DRUGS CONTAINING THE SAME

Title:

PROSTACYCLINS AND DRUGS CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1987/001696

Kind Code:

A1

Abstract:

Novel prostacyclins represented by general formula (I), wherein R1 represents -CO2R5 or -CONR6R7, A represents (i) -CH=CH-CH2CH2- or (ii) -CH2CH2-O-CH2-, B represents -C=C-, R2 represents alkyl, cycloalkyl, alkenyl, alkynyl, phenyl or phenoxy, R3 represents H, methyl or vinyl, R4 represents H, acyl, tri(C1-7 hydrocarbon)silyl, or a group forming an acetal bond together with the oxygen atom or the hydroxy group, the double bond of the substituent represented by A is E, Z, or a mixture thereof, and the asymmetric center of the substituent represented by R2 is R- or S-conformation, or a mixture thereof and their use as drugs for improving blood circulation or for antithrombotic use, or as antiulcer drugs.

Inventors:

SHIBASAKI MASAKATSU (JP)
SODEOKA MIKIKO (JP)
ISEKI KATSUHIKO (JP)
SHINODA MASAKI (JP)
AOKI CHIYOKO (JP)
HAYASHI YOSHIO (JP)
KANAYAMA TOSHIJI (JP)

Application Number:

PCT/JP1986/000486

Publication Date:

March 26, 1987

Filing Date:

September 18, 1986

Export Citation:

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Assignee:

MITSUBISHI CHEM IND (JP)
SAGAMI CHEM RES (JP)

International Classes:

A61K31/557; A61K31/695; A61P1/04; A61P7/02; A61P9/08; A61P9/12; C07C51/00; C07C59/46; C07C59/54; C07C59/62; C07C59/64; C07C59/72; C07C59/125; C07C67/00; C07C69/03; C07C69/708; C07C69/732; C07C69/734; C07C231/00; C07C235/06; C07C235/30; C07C235/34; C07C405/00; C07D295/18; C07F7/18; (IPC1-7): C07C59/125; C07C59/46; C07C59/62; C07C69/708; C07C69/732; C07C69/734; C07C103/19; C07C103/175; C07C103/58; C07C103/737; C07F7/18; A61K31/557

Foreign References:

JPS61129146A	1986-06-17
JPS59137445A	1984-08-07
JPS57145833A	1982-09-09
JPH05982339A

Other References: