Title:
PROSTATE CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL
Document Type and Number:
WIPO Patent Application WO/2010/056993
Kind Code:
A3
Abstract:
Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a subject one or more biomarkers selected from the group consisting of FOXO1A, SOX9, CLNS1A, PTGDS, XPO1, LETMD1, RAD23B, ABCC3, APC, CHES1, EDNRA, FRZB, HSPG2, and TMPRSS2_ETV1 FUSION. The method can further comprise detecting in a sample from a subject one or more biomarkers selected from the group consisting of miR-103, miR-339, miR-183, miR-182, miR-136, and miR-221. An increase or decrease in one or more biomarkers as compared to a standard indicates a recurrent, progressive, or metastatic prostate cancer.
Inventors:
MORENO CARLOS (US)
OSUNKOYA ADEBOYE (US)
ZHOU WEI (US)
LEYLAND-JONES BRIAN (US)
LONG QI (US)
JOHNSON BRENT A (US)
OSUNKOYA ADEBOYE (US)
ZHOU WEI (US)
LEYLAND-JONES BRIAN (US)
LONG QI (US)
JOHNSON BRENT A (US)
Application Number:
PCT/US2009/064384
Publication Date:
September 30, 2010
Filing Date:
November 13, 2009
Export Citation:
Assignee:
UNIV EMORY (US)
MORENO CARLOS (US)
OSUNKOYA ADEBOYE (US)
ZHOU WEI (US)
LEYLAND-JONES BRIAN (US)
LONG QI (US)
JOHNSON BRENT A (US)
MORENO CARLOS (US)
OSUNKOYA ADEBOYE (US)
ZHOU WEI (US)
LEYLAND-JONES BRIAN (US)
LONG QI (US)
JOHNSON BRENT A (US)
International Classes:
C12Q1/68; C12N15/12; G16B25/10; G16B40/00; G16B40/30
Domestic Patent References:
| WO2007093657A2 | 2007-08-23 |
Other References:
DONG, X. ET AL.: "FOX01A is a Candidate for the 13q14 Tumor Supressor Gene Inhibiting Androgen Receptor Signaling in Prostate Cancer", CANCER RES(2006), vol. 61, 15 July 2006 (2006-07-15)
DALLAS, P.B. ET AL.: "Aberrant over-expression of a forkhead family member, FOX01A, in a brain tumor cell line", BMC CANCER(2007), vol. 7, no. 67, 19 April 2007 (2007-04-19)
DALLAS, P.B. ET AL.: "Aberrant over-expression of a forkhead family member, FOX01A, in a brain tumor cell line", BMC CANCER(2007), vol. 7, no. 67, 19 April 2007 (2007-04-19)
Download PDF:
Previous Patent: METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES
Next Patent: METHODS AND SYSTEMS FOR MODULAR BUILDINGS
Next Patent: METHODS AND SYSTEMS FOR MODULAR BUILDINGS