PROSTATE STEM CELL ANTIGEN VACCINES AND USES THEREOF

Title:

PROSTATE STEM CELL ANTIGEN VACCINES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO2006076678

Kind Code:

A9

Abstract:

This invention relates to the identification of prostate stem cell antigen (PSCA) as a target of clinically relevant antitumor immune responses. The invention provides vaccines comprising PSCA, or fragments thereof, which are useful in inducing antitumor immune responses, including PSCA specific CD8+ T cell responses. Methods of using the compositions to treat cancer are also provided. The invention further provides methods of identifying compounds useful in antitumor vaccines and methods of assessing the responses of patients to cancer immunotherapy.

Inventors:

JAFFEE ELIZABETH M (US)

Application Number:

PCT/US2006/001424

Publication Date:

January 11, 2007

Filing Date:

January 13, 2006

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS (US)
JAFFEE ELIZABETH M (US)

International Classes:

A61K39/00

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