Title:
PROSTHESIS FOR IN VIVO INSERTION, COATED WITH CROSS-LINKED POLYPHOSPHORYLCHOLINE
Document Type and Number:
WIPO Patent Application WO/2015/160218
Kind Code:
A1
Abstract:
The present invention relates to: a coating composition for a prosthesis for in vivo insertion, comprising a photoinitiator, a cross-linking agent and a phosphorylcholine (PC) monomer having an acrylate group; a method for coating a prosthesis for in vivo insertion by using the coating composition; and a cosmetic prosthesis coated with cross-linked polyphosphorylcholine. A prosthesis for in vivo insertion, which is coated with cross-linked polyphosphorylcholine, can be prepared by a simple method adding the coating composition, which contains a photoinitiator, a cross-linking agent and a PC monomer having an acrylate group, according to the present invention, and emitting ultraviolet rays, and the cross-linked polyphosphorylcholine coating provides hydrophilicity to a surface and can remarkably reduce the adhesion of fibroblasts capable of inducing side effects such as protein and capsular construction. In addition, the coating does not come off even with intense motion and the like after in vivo insertion due to a coating strength such that the coating does not come off even by stimulation, and thus the present invention can be useful for the preparation of a prosthesis for in vivo insertion with reduced side effects, such as a prosthesis for mammaplasty.
Inventors:
CHOI TAE HYUN (KR)
LEE YAN (KR)
PARK JI UNG (KR)
HAM JI YEON (KR)
KIM HEE JIN (KR)
KIM SUK WHA (KR)
MIN HYE JEONG (KR)
LEE YAN (KR)
PARK JI UNG (KR)
HAM JI YEON (KR)
KIM HEE JIN (KR)
KIM SUK WHA (KR)
MIN HYE JEONG (KR)
Application Number:
PCT/KR2015/003879
Publication Date:
October 22, 2015
Filing Date:
April 17, 2015
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
International Classes:
A61L27/34; A61F2/12; A61L27/32
Domestic Patent References:
| WO2011086537A2 | 2011-07-21 | |||
| WO2003030940A1 | 2003-04-17 |
Foreign References:
| US20050266038A1 | 2005-12-01 | |||
| KR20060015624A | 2006-02-17 |
Other References:
GODA, T. ET AL.: "Biomimetic phosphorylcholine polymer grafting from polydimethylsiloxane surface using photo-induced polymerization", BIOMATERIALS, vol. 27, 2006, pages 5151 - 5160, XP027951171
See also references of EP 3132810A4
See also references of EP 3132810A4
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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