Title:
PROTAC COMPOUND WITH CYCLOPHILIN A DEGRADATION ACTIVITY, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/031965
Kind Code:
A1
Abstract:
Disclosed are a PROTAC compound with cyclophilin A degradation activity, a preparation method therefor, and use thereof. The structural formula of the PROTAC compound is represented by formula (I). The compound represented by formula (I) provided by the present invention can be used for preventing and/or treating CypA-mediated diseases, such as CypA-mediated inflammation, autoimmune diseases, and/or tumors. The present invention also provides a pharmaceutical composition comprising the compound represented by formula I as an active ingredient and at least one pharmaceutically acceptable carrier, excipient, and/or diluent. The PROTAC compound provided by the present invention can degrade CypA protein in a targeted manner, so that the PROTAC compound can be used for preparing medicaments for treating inflammation, autoimmune diseases, tumors, and other related diseases. The compound represented by formula I in the present invention has a significant inhibitory function on virus-induced pneumonia, rheumatoid arthritis, and lung cancer cell migration and infiltration.
Inventors:
LIU WENJUN (CN)
SUN LEI (CN)
LI HEQIAO (CN)
YANG WENXIAN (CN)
BAI XIAOYUAN (CN)
ZHANG HE (CN)
SUN LEI (CN)
LI HEQIAO (CN)
YANG WENXIAN (CN)
BAI XIAOYUAN (CN)
ZHANG HE (CN)
Application Number:
PCT/CN2023/078658
Publication Date:
February 15, 2024
Filing Date:
February 28, 2023
Export Citation:
Assignee:
SHENZHEN BAY LABORATORY (CN)
International Classes:
C07K5/062; A61K38/05; A61P29/00; A61P35/00; A61P37/02; C07K1/02; C07K1/12
Domestic Patent References:
| WO2021232098A1 | 2021-11-25 | |||
| WO2021190603A1 | 2021-09-30 |
Foreign References:
| CN115028679A | 2022-09-09 | |||
| CN106432025A | 2017-02-22 | |||
| US20140213508A1 | 2014-07-31 | |||
| US20130324480A1 | 2013-12-05 | |||
| US20140050728A1 | 2014-02-20 |
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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