Title:
PROTAC SMALL MOLECULE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057872
Kind Code:
A1
Abstract:
Disclosed are a compound represented by general formula (I) or a pharmaceutically acceptable salt, stereoisomer, ester, prodrug, solvate and deuterated compound thereof, a composition which comprises the compound represented by general formula (I), and an application of the compound represented by general formula (I) or the pharmaceutically acceptable salt, stereoisomer, ester, prodrug, solvate and deuterated compound thereof in the preparation of a drug to treat diseases related to the serine/threonine kinase family (MAP4Ks), preferably being an application in a drug for diseases related to hematopoietic stem cell kinase 1 (HPK1).
Inventors:
LIAO XUEBIN (CN)
SUN SHUHAO (CN)
LIN XINGYU (CN)
LIU YAHUI (CN)
SUN SHUHAO (CN)
LIN XINGYU (CN)
LIU YAHUI (CN)
Application Number:
PCT/CN2020/117573
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
ZHUHAI YUFAN BIOTECHNOLOGIES CO LTD (CN)
UNIV TSINGHUA (CN)
UNIV TSINGHUA (CN)
International Classes:
C07D417/14; A61K31/44; A61K31/45; A61P35/00; C07D401/14; C07D405/14; C07D417/04
Domestic Patent References:
| WO2019206049A1 | 2019-10-31 |
Foreign References:
| CN110204543A | 2019-09-06 | |||
| CN110396087A | 2019-11-01 | |||
| CN110396088A | 2019-11-01 | |||
| CN108366992A | 2018-08-03 | |||
| CN110234646A | 2019-09-13 | |||
| CN201810945948A | 2018-08-20 | |||
| CN201810946081A | 2018-08-20 |
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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