Title:
PROTEASE INHIBITOR PEPTIDES
Document Type and Number:
WIPO Patent Application WO1999063090
Kind Code:
A3
Abstract:
Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to an inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogs, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogs and systems for expression of the peptides of the invention are provided.
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Inventors:
WHITE R TYLER (US)
DAMM DEBORAH (US)
LESIKAR DAVID D (US)
MCFADDEN KATHLEEN (US)
GARRICK BRETT L (US)
LUCAS ANNE BERGSTROM (US)
POLLITT N STEPHEN (US)
LAM ANDREW O (US)
DAMM DEBORAH (US)
LESIKAR DAVID D (US)
MCFADDEN KATHLEEN (US)
GARRICK BRETT L (US)
LUCAS ANNE BERGSTROM (US)
POLLITT N STEPHEN (US)
LAM ANDREW O (US)
Application Number:
PCT/US1999/012276
Publication Date:
March 02, 2000
Filing Date:
June 03, 1999
Export Citation:
Assignee:
SCIOS INC (US)
WHITE R TYLER (US)
DAMM DEBORAH (US)
LESIKAR DAVID D (US)
MCFADDEN KATHLEEN (US)
GARRICK BRETT L (US)
LUCAS ANNE BERGSTROM (US)
POLLITT N STEPHEN (US)
LAM ANDREW O (US)
WHITE R TYLER (US)
DAMM DEBORAH (US)
LESIKAR DAVID D (US)
MCFADDEN KATHLEEN (US)
GARRICK BRETT L (US)
LUCAS ANNE BERGSTROM (US)
POLLITT N STEPHEN (US)
LAM ANDREW O (US)
International Classes:
C12N15/09; A61K38/55; A61P43/00; C07K14/47; C07K14/81; C12N1/19; C12N1/21; C12N15/15; C12P21/02; A61K38/00; C12R1/865; (IPC1-7): C12N15/15; A61K38/57; C07K14/81; C12N1/19; C12N1/21
Domestic Patent References:
| WO1996035788A2 | 1996-11-14 | |||
| WO1993009233A2 | 1993-05-13 |
Foreign References:
| US5663143A | 1997-09-02 |
Other References:
LEHNINGER A: "Biochemistry", 1972, WORTH PUBLISHERS, NEW YORK, XP002125112
DENNIS M S ET AL: "KUNITZ DOMAIN INHIBITORS OF TISSUE FACTOR-FACTOR VIIA. II. POTENT AND SPECIFIC INHIBITORS BY COMPETITIVE PHAGE SELECTION", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 35, pages 22137-22144, XP002015892, ISSN: 0021-9258
DENNIS M S ET AL: "KUNITZ DOMAIN INHIBITORS OF TISSUE FACTOR-FACTOR VIIA. II. POTENT AND SPECIFIC INHIBITORS BY COMPETITIVE PHAGE SELECTION", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 35, pages 22137-22144, XP002015892, ISSN: 0021-9258
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