Title:
PROTEASE-RESISTANT SYSTEMS FOR POLYPEPTIDE DISPLAY AND METHODS OF MAKING AND USING THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/026136
Kind Code:
A3
Abstract:
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.
Inventors:
LA PORTE SHERRY (US)
WEST JAMES WILLIAM (US)
MOORE STEPHEN JAMES (US)
WEST JAMES WILLIAM (US)
MOORE STEPHEN JAMES (US)
Application Number:
PCT/US2013/054378
Publication Date:
May 08, 2014
Filing Date:
August 09, 2013
Export Citation:
Assignee:
CYTOMX THERAPEUTICS INC (US)
International Classes:
C12N1/21
Foreign References:
| US20070065878A1 | 2007-03-22 | |||
| US20050196406A1 | 2005-09-08 | |||
| US20070099267A1 | 2007-05-03 |
Other References:
See also references of EP 2882844A4
Attorney, Agent or Firm:
ELRIFI, Ivor, R. et al. (P.C.One Financial Cente, Boston MA, US)
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