Title:
PROTEASE SELECTIVE SUPRAMOLECULAR ASSEMBLIES
Document Type and Number:
WIPO Patent Application WO/2012/050896
Kind Code:
A3
Abstract:
Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.
Inventors:
BOSSMANN STEFAN H (US)
TROYER DERYL L (US)
BASEL MATTHEW T (US)
SHRESTHA TEJ B (US)
WANG HONGWANG (US)
TROYER DERYL L (US)
BASEL MATTHEW T (US)
SHRESTHA TEJ B (US)
WANG HONGWANG (US)
Application Number:
PCT/US2011/053711
Publication Date:
June 14, 2012
Filing Date:
September 28, 2011
Export Citation:
Assignee:
UNIV KANSAS STATE (US)
BOSSMANN STEFAN H (US)
TROYER DERYL L (US)
BASEL MATTHEW T (US)
SHRESTHA TEJ B (US)
WANG HONGWANG (US)
BOSSMANN STEFAN H (US)
TROYER DERYL L (US)
BASEL MATTHEW T (US)
SHRESTHA TEJ B (US)
WANG HONGWANG (US)
International Classes:
A61K9/127; A61K47/48; A61K49/18
Domestic Patent References:
| WO2009111470A2 | 2009-09-11 |
Foreign References:
| US20050239170A1 | 2005-10-27 | |||
| US20020035082A1 | 2002-03-21 | |||
| US20040180094A1 | 2004-09-16 | |||
| US20050123563A1 | 2005-06-09 |
Other References:
M. T. BASEL ET AL.: "Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release", ACS NANO, vol. 5, no. 3, 22 March 2011 (2011-03-22), pages 2162 - 2175
Attorney, Agent or Firm:
COOK, Crissa A. (10801 Mastin Blvd. Suite 100084 Corporate Wood, Overland Park Kansas, US)
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