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Title:
PROTEASE-STABLE PROTEINS
Document Type and Number:
WIPO Patent Application WO/1993/011254
Kind Code:
A1
Abstract:
A protein with improved stability against proteolytic degradation is provided, wherein one or more protease labile amino acid segments are substituted by protease non-labile amino acid segment(s). The protein to be stabilized is advantageously an enzyme, e.g. of microbial origin, such as a lipase, for instance a lipase derived from a strain of Humicola, e.g. H. lanuginosa, or Rhizomucor, e.g. R. miehei. The stabilized protein may be produced by recombinant DNA techniques and may advantageously be used for detergent purposes.

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Inventors:
SVENDSEN ALLAN (DK)
CLAUSEN IB GROTH (DK)
PATHAR SHAMKANT ANANT (DK)
Application Number:
PCT/DK1992/000351
Publication Date:
June 10, 1993
Filing Date:
November 26, 1992
Export Citation:
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Assignee:
NOVO NORDISK AS (DK)
International Classes:
C12N15/09; C07K9/00; C11D3/386; C11D7/42; C12N1/15; C12N9/20; C12N15/55; C12P19/38; C12P21/02; C12R1/19; C12R1/645; C11D; C12N; (IPC1-7): C11D3/386; C12N9/20; C12N15/55; C12P21/02
Foreign References:
EP0407225A11991-01-09
EP0305216A11989-03-01
Other References:
Science, Volume 234, November 1986, J.F. LESZCZYNSKI et al., "Loops in Globular Proteins: A Novel Category of Secondary Structure", page 849 - page 855.
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