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Title:
PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/014068
Kind Code:
A1
Abstract:
The invention relates to 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilone and epothilone derivatives and a method for producing said novel intermediate products in the synthesis and the use thereof in the production of epothilones or epothilone derivatives.

Inventors:
Westermann, Jürgen (Schwalbacher Str. 7 Berlin, 12161, DE)
Petrov, Orlin (Friedrichshaller Str. 7b Berlin, 14199, DE)
Platzek, Johannes (Grottkauer Str. 55 Berlin, 12621, DE)
Application Number:
PCT/EP2002/008730
Publication Date:
February 20, 2003
Filing Date:
August 05, 2002
Export Citation:
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Assignee:
SCHERING AKTIENGESELLSCHAFT (Müllerstr. 178 Berlin, 13353, DE)
International Classes:
C07C255/16; C07B53/00; C07B61/00; C07C45/42; C07C49/175; C07C253/30; C07C255/12; C07C255/13; C07C255/20; C07C255/21; C07D319/06; C07F7/08; C07F7/10; C07F7/18; C12P13/00; C12P41/00; (IPC1-7): C07C255/16; C07D319/06; C07F7/18; C07C253/30; C07D301/02
Domestic Patent References:
WO2000058254A12000-10-05
Other References:
SCHINZER D ET AL: "CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US", CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US, vol. 2, no. 11, 1996, pages 1477 - 1482, XP002095724, ISSN: 0947-6539
SCHINZER D ET AL: "ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 109, no. 5, 1997, pages 543 - 544, XP002095720, ISSN: 0044-8249
JOHANN MULZER ET AL: "Total Syntheses of Epothilones B and D", J. ORG. CHEM., vol. 65, no. 22, 2000, pages 7456 - 7467, XP002218886
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