PROTEIN-BINDING DRUG

WIPO Patent Application WO/2019/103050

A1

Provided is a compound that, after administration into an organism, rapidly binds to blood albumin, persistently circulates systemically, and efficiently accumulates in tumor tissue and then releases an active drug. The compound exhibits a high concentration in tumor tissue, an excellent anti-tumor effect, and reduced adverse effects. The present invention provides a compound represented by general formula (I) [the definitions of the individual symbols in the formula are as described in the Description] or a pharmaceutically acceptable salt thereof, which can provide an excellent anti-cancer agent that exhibits an excellent anti-cancer action on cancer cells while producing few adverse effects.

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SHOJI YOSHIMICHI (JP)
OTAKE KAZUYA (JP)
MORISHITA KO (JP)
KITAO TATSUYA (JP)

PCT/JP2018/043032

May 31, 2019

November 21, 2018

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KYOTO PHARMA IND (JP)

C07D401/12; A61K31/4545; A61K31/519; A61K31/704; A61K31/7068; A61K47/42; A61K47/64; A61P35/00; A61P35/04; C07D401/14; C07D403/12; C07D471/04; C07H15/26; C07H19/067; C07H19/073

JP2003501486A	2003-01-14
JPH072895A	1995-01-06
JP2015508414A	2015-03-19

TAKASHIMA, Hajime et al. (JP)

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