Title:
PROTEIN BINDING TO FIBRONECTIN B DOMAIN
Document Type and Number:
WIPO Patent Application WO/2019/062877
Kind Code:
A1
Abstract:
The present invention relates to an epitope on a fibronectin B (ED-B) domain, more specifically to an antibody or an antibody fragment of an ED-B domain, and can be widely applied in in-vitro detection and in-vivo positioning of ED-B domains as well as in targeted cancer therapy.
Inventors:
ZHANG MEI (CN)
JI JUNQIU (CN)
GAO MEIHUA (CN)
CHEN JUN (CN)
JI JUNQIU (CN)
GAO MEIHUA (CN)
CHEN JUN (CN)
Application Number:
PCT/CN2018/108532
Publication Date:
April 04, 2019
Filing Date:
September 29, 2018
Export Citation:
Assignee:
HEFEI LIFEON PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/18; A61K39/395; A61P35/00; C12N15/13; C12N15/63; G01N33/68
Domestic Patent References:
| WO2007054120A1 | 2007-05-18 | |||
| WO1997045544A1 | 1997-12-04 | |||
| WO2014194784A1 | 2014-12-11 | |||
| WO1993011161A1 | 1993-06-10 |
Foreign References:
| US20030176663A1 | 2003-09-18 | |||
| CN104395342B | 2017-07-04 | |||
| CN1219968A | 1999-06-16 | |||
| EP0404097A2 | 1990-12-27 | |||
| US4816567A | 1989-03-28 |
Other References:
VENTURA, E: "C6:A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat 1118.", PLOS ONE, 2 November 2016 (2016-11-02), XP055588784
MENRAD, A.: "ED-B fibronectin as a target for antibody-based cancer treatments", EXPERT OPINION ON THERAPEUTIC TARGETS, 10 June 2005 (2005-06-10), XP009052148
CARNEMOLLA, LEPRINI ET AL., J BIOL CHEM, 1992, pages 24689 - 24692
CARNEMOLLA, NERI ET AL., INT J CANCER, 1996, pages 397 - 405
PINI, VITI ET AL., J BIOL CHEM, 1998, pages 21769 - 21776
KIPRIYANOV: "Recombinant Antibodies for Cancer Therapy Methods and Protocols", METHODS IN MOLECULAR BIOLOGY, vol. 207, 2003, pages 3 - 25
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
WU, A. M.P. D. SENTER, NAT BIOTECHNOL, vol. 23, no. 9, 2005, pages 1137 - 1146
"The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
PRESTA, J. ALLERGY CLIN. IMMUNOL., vol. 116, 2005, pages 731
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING CO.
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", 1985, MACMILLAN PUBLISHING CO.
SMITH ET AL., J. CLIN. PATHOL., vol. 57, 2004, pages 912 - 917
NELSON ET AL., J CLIN PATHOL, vol. 53, 2000, pages 111 - 117
BEATTY ET AL., J IMMUNOL METHODS, 1987, pages 173 - 179
LEAHYAUKHIL ET AL., CELL, 1996, pages 155 - 164
SCHIEFNERGEBAUER ET AL., J BIOL CHEM, 2012, pages 17578 - 17588
TOMLINSON, I. M.WALTER, G.MARKS, J. D.LLEWELYN, M. B.WINTER, G.: "The repertoire of human germline VH segments reveals about fifty groups of VH segments with different hypervariable loops", J. MOL. BIOL., vol. 227, 1992, pages 776 - 798, XP024020607, DOI: 10.1016/0022-2836(92)90223-7
WILLIAMS, S. C.WINTER, G.: "Cloning and sequencing of human immunoglobulin V lambda gene segments", EUR. J. IMMUNOL., vol. 23, 1993, pages 1456 - 1461
LI, R. ET AL., J BIOL CHEM, vol. 279, no. 25, 2004, pages 26666 - 26673
See also references of EP 3689903A4
MENRAD, A.: "ED-B fibronectin as a target for antibody-based cancer treatments", EXPERT OPINION ON THERAPEUTIC TARGETS, 10 June 2005 (2005-06-10), XP009052148
CARNEMOLLA, LEPRINI ET AL., J BIOL CHEM, 1992, pages 24689 - 24692
CARNEMOLLA, NERI ET AL., INT J CANCER, 1996, pages 397 - 405
PINI, VITI ET AL., J BIOL CHEM, 1998, pages 21769 - 21776
KIPRIYANOV: "Recombinant Antibodies for Cancer Therapy Methods and Protocols", METHODS IN MOLECULAR BIOLOGY, vol. 207, 2003, pages 3 - 25
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
WU, A. M.P. D. SENTER, NAT BIOTECHNOL, vol. 23, no. 9, 2005, pages 1137 - 1146
"The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
PRESTA, J. ALLERGY CLIN. IMMUNOL., vol. 116, 2005, pages 731
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING CO.
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", 1985, MACMILLAN PUBLISHING CO.
SMITH ET AL., J. CLIN. PATHOL., vol. 57, 2004, pages 912 - 917
NELSON ET AL., J CLIN PATHOL, vol. 53, 2000, pages 111 - 117
BEATTY ET AL., J IMMUNOL METHODS, 1987, pages 173 - 179
LEAHYAUKHIL ET AL., CELL, 1996, pages 155 - 164
SCHIEFNERGEBAUER ET AL., J BIOL CHEM, 2012, pages 17578 - 17588
TOMLINSON, I. M.WALTER, G.MARKS, J. D.LLEWELYN, M. B.WINTER, G.: "The repertoire of human germline VH segments reveals about fifty groups of VH segments with different hypervariable loops", J. MOL. BIOL., vol. 227, 1992, pages 776 - 798, XP024020607, DOI: 10.1016/0022-2836(92)90223-7
WILLIAMS, S. C.WINTER, G.: "Cloning and sequencing of human immunoglobulin V lambda gene segments", EUR. J. IMMUNOL., vol. 23, 1993, pages 1456 - 1461
LI, R. ET AL., J BIOL CHEM, vol. 279, no. 25, 2004, pages 26666 - 26673
See also references of EP 3689903A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
Download PDF:
Previous Patent: FLUORESCENT PROBE, PREPARATION METHOD THEREFOR AND USE THEREOF
Next Patent: HYBRID VEHICLE AND POWER SYSTEM THEREOF
Next Patent: HYBRID VEHICLE AND POWER SYSTEM THEREOF