Title:
PROTEIN DEGRADING AGENT AND USE THEREOF IN TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/078301
Kind Code:
A1
Abstract:
Disclosed are compounds of formulae (I) and (II), or a salt, enantiomer, stereoisomer, solvate or polymorph thereof, and the use thereof for treating diseases. R 1-A 1-LIN-A 2-R 2 (I) R 12-A 12-LIN-A 22-R 22 (II)
Inventors:
YANG XIAOBAO (CN)
JIANG BIAO (CN)
TAN WENFU (CN)
XU ZHONGLI (CN)
LUO JIA (CN)
WANG JUAN (CN)
YANG JUN (CN)
ZHANG SHAOQING (CN)
JIANG BIAO (CN)
TAN WENFU (CN)
XU ZHONGLI (CN)
LUO JIA (CN)
WANG JUAN (CN)
YANG JUN (CN)
ZHANG SHAOQING (CN)
Application Number:
PCT/CN2020/123731
Publication Date:
April 29, 2021
Filing Date:
October 26, 2020
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
UNIV FUDAN (CN)
UNIV FUDAN (CN)
International Classes:
A61K31/45; A61K31/4439; A61K31/496; A61K31/635; A61P35/00; C07D401/04; C07D401/14; C07D417/14; C07D471/04
Domestic Patent References:
| WO2017184995A1 | 2017-10-26 | |||
| WO2015160845A2 | 2015-10-22 | |||
| WO2012071374A1 | 2012-05-31 | |||
| WO2014113413A1 | 2014-07-24 |
Foreign References:
| US20190054097A1 | 2019-02-21 |
Other References:
VARNES, JEFFREY G. ET AL.,: "Towards the next generation of dual Bcl-2/Bcl-xL inhibitors,", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, 20 May 2014 (2014-05-20), XP029033886, DOI: 10.1016/j.bmcl.2014.05.036
Attorney, Agent or Firm:
SYNCLAW ATTORNEYS (CN)
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