Title:
PROTEIN DESIGN AUTOMATION FOR DESIGNING PROTEIN LIBRARIES WITH ALTERED IMMUNOGENICITY
Document Type and Number:
WIPO Patent Application WO2003006154
Kind Code:
A3
Abstract:
The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, proteins will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.
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Inventors:
CHIRINO ARTHUR
DAHIYAT BASSIL I
DESJARLAIS JOHN
DAHIYAT BASSIL I
DESJARLAIS JOHN
Application Number:
PCT/US2002/000165
Publication Date:
October 13, 2005
Filing Date:
January 04, 2002
Export Citation:
Assignee:
XENCOR INC (US)
International Classes:
C07K1/00; C07K1/04; C07K14/47; C07K14/765; (IPC1-7): G06F19/00
Other References:
OSTANKOVITCH M ET AL: "A PARTIALLY MODIFIED RETRO-INVERSO PSEUDOPEPTIDE MODULATES THE CYTOKINE PROFILE OF CTL SPECIFIC FOR AN INFLUENZA VIRUS EPITOPE", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, 1998, pages 200 - 208, XP002933305, ISSN: 0022-1767
SCHUELER-FURMAN O ET AL: "Knowledge-based structure prediction of MHC class I bound peptides: a study of 23 complexes.", FOLDING & DESIGN. 1998, vol. 3, no. 6, 1998, pages 549 - 564, XP002317413, ISSN: 1359-0278
SCHUELER-FURMAN O ET AL: "Knowledge-based structure prediction of MHC class I bound peptides: a study of 23 complexes.", FOLDING & DESIGN. 1998, vol. 3, no. 6, 1998, pages 549 - 564, XP002317413, ISSN: 1359-0278
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