Title:
PROTEIN EXHIBITING FATTY ACID ELONGATION PROMOTING ACTIVITY, GENE ENCODING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/018879
Kind Code:
A1
Abstract:
The present invention relates to fatty acid elongation promoting activity and polynucleotides encoding same, and the like. The present invention provides: polynucleotides comprising a base sequence set forth in SEQ ID NO:1 or SEQ ID NO:4; polynucleotides encoding proteins comprising the amino acid sequence set forth in SEQ ID NO:2; expression vectors and transformants which comprise these polynucleotides; a preparation method for lipids or fatty acids which uses said transformants; and food products, or the like, comprising the lipids or fatty acids prepared by such a preparation method.
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Inventors:
OCHIAI MISA (JP)
Application Number:
PCT/JP2012/069792
Publication Date:
February 07, 2013
Filing Date:
August 03, 2012
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
OCHIAI MISA (JP)
OCHIAI MISA (JP)
International Classes:
C12N15/09; A23L1/30; A61K8/36; A61K8/37; A61K31/19; A61K31/22; C12N1/15; C12N1/19; C12N9/02; C12P7/64; C12R1/645
Domestic Patent References:
| WO2010147138A1 | 2010-12-23 |
Foreign References:
| JP2005287403A | 2005-10-20 |
Other References:
TAKASHI KOBAYASHI: "Biseibutsu wa Kisho Yushi no Hoko!?", BIOTECHNOLOGY, vol. 88, no. 1, 25 January 2010 (2010-01-25), pages 22, XP008173242
PARKER-BARNES JM. ET AL.: "Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids.", PROC NATL ACAD SCI U S A., vol. 97, no. 15, 18 July 2000 (2000-07-18), pages 8284 - 8289, XP002992660
SEIKI TAKENO ET AL.: "Arachidonic Acid Seisansei Shijokin Mortierella alpina 1S-4 ni Okeru Shibosan Sacho Enchoka Koso (GLELO) Idenshi Hatsugen ni yoru Shibosan Sosei no Kaihen", 2004 NENDO (HEISEI 16 NENDO) JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 5 March 2004 (2004-03-05), pages 25, XP008133551
EIJI SAKURADANI ET AL.: "Arachidonic Acid Seisansei Shijokin Mortierella alpina 1S-4 no Shibosan Sacho Encho Koso Idenshi no Kozo to Kino no Kaimei", 2010 NENDO (HEISEI 22 NENDO) JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 5 March 2010 (2010-03-05), pages 95, XP008173155
KIHARA A. ET AL., J. BIOL. CHEM., vol. 283, 2008, pages 11199 - 11209
HAN, G. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35440 - 35449
ATHENSTAEDT, K.; DAUM, G., J. BIOL. CHEM., vol. 275, 2000, pages 235 - 240
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
HAN, G ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35440 - 35449
MYCOTAXON, vol. XLIV, no. 2, 1992, pages 257 - 265
APPL. MICROBIOL. BIOTECHNOL., vol. 65, 2004, pages 419 - 425
BIOSCI. BIOTECH. BIOCHEM., vol. 59, 1995, pages 1221 - 1228
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
MACKENXIE D. A. ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages L929
J. BACTERIOLOGY, vol. 153, 1983, pages L63
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
APPL. MICROBIOL. BIOTECHNOL., vol. 30, 1989, pages 515 - 520
See also references of EP 2740797A4
PARKER-BARNES JM. ET AL.: "Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids.", PROC NATL ACAD SCI U S A., vol. 97, no. 15, 18 July 2000 (2000-07-18), pages 8284 - 8289, XP002992660
SEIKI TAKENO ET AL.: "Arachidonic Acid Seisansei Shijokin Mortierella alpina 1S-4 ni Okeru Shibosan Sacho Enchoka Koso (GLELO) Idenshi Hatsugen ni yoru Shibosan Sosei no Kaihen", 2004 NENDO (HEISEI 16 NENDO) JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 5 March 2004 (2004-03-05), pages 25, XP008133551
EIJI SAKURADANI ET AL.: "Arachidonic Acid Seisansei Shijokin Mortierella alpina 1S-4 no Shibosan Sacho Encho Koso Idenshi no Kozo to Kino no Kaimei", 2010 NENDO (HEISEI 22 NENDO) JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, 5 March 2010 (2010-03-05), pages 95, XP008173155
KIHARA A. ET AL., J. BIOL. CHEM., vol. 283, 2008, pages 11199 - 11209
HAN, G. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35440 - 35449
ATHENSTAEDT, K.; DAUM, G., J. BIOL. CHEM., vol. 275, 2000, pages 235 - 240
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
HAN, G ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35440 - 35449
MYCOTAXON, vol. XLIV, no. 2, 1992, pages 257 - 265
APPL. MICROBIOL. BIOTECHNOL., vol. 65, 2004, pages 419 - 425
BIOSCI. BIOTECH. BIOCHEM., vol. 59, 1995, pages 1221 - 1228
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
MACKENXIE D. A. ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages L929
J. BACTERIOLOGY, vol. 153, 1983, pages L63
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
APPL. MICROBIOL. BIOTECHNOL., vol. 30, 1989, pages 515 - 520
See also references of EP 2740797A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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