Title:
PROTEIN FRACTIONATION AND SINGLE POLYMER MATRIX UNIT CHROMATOGRAPHY
Document Type and Number:
WIPO Patent Application WO2002094407
Kind Code:
A3
Abstract:
A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or chemical properties; (b) contacting the fluid with at least two individual polymer matrix units, each polymer matrix unit preferentially accepting a different set of polypeptides on the basis of one or more physical and/or chemical properties; and (c) extracting the set of polypeptides from each polymer matrix unit.
Inventors:
MAUGHAN DAVID W
Application Number:
PCT/US2002/016202
Publication Date:
September 15, 2005
Filing Date:
May 22, 2002
Export Citation:
Assignee:
UNIV VERMONT (US)
International Classes:
C07K1/20; C07K1/36; A61K38/00; (IPC1-7): G01N33/53; G01N33/558
Foreign References:
| US4590002A | 1986-05-20 | |||
| US5434079A | 1995-07-18 |
Other References:
OLESCHUK R.D. ET AL: "Trapping of Bead-Based Reagents Within Microfluidic Systems: On-Chip Solid-PhaseExtraction and Electrochromatography", ANAL CHEM, vol. 72, no. 3, February 2000 (2000-02-01), pages 585 - 590, XP001074756
TAKEI N. ET AL: "Monitoring of Acetylcholine Released from Postnatal Rat Basal Forebrain Cholinergic Neurons Cultured on Membrane Filter by Cell Bed Perfusion System andHPLC-ECD.", EXPERIMENTAL NEUROLOGY, vol. 108, June 1990 (1990-06-01), pages 229 - 231, XP002988653
TAKEI N. ET AL: "Monitoring of Acetylcholine Released from Postnatal Rat Basal Forebrain Cholinergic Neurons Cultured on Membrane Filter by Cell Bed Perfusion System andHPLC-ECD.", EXPERIMENTAL NEUROLOGY, vol. 108, June 1990 (1990-06-01), pages 229 - 231, XP002988653
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