A PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY USES THEREOF

Title:

A PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2012/151234

Kind Code:

A3

Abstract:

A method of generating protein-induced pluripotent stem cells by delivering bacterial!y expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.

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Inventors:

WANG JIANJUN (US)
LI QIANQIAN (US)

Application Number:

PCT/US2012/036051

Publication Date:

February 20, 2014

Filing Date:

May 02, 2012

Export Citation:

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Assignee:

UNIV WAYNE STATE (US)
WANG JIANJUN (US)
LI QIANQIAN (US)

International Classes:

A01N63/00; C12N5/00; C12N5/071

Foreign References:

US20100233804A1	2010-09-16
US20090298111A1	2009-12-03

Other References: