Title:
PROTEIN-PROTEIN INTERACTIONS
Document Type and Number:
WIPO Patent Application WO2002050303
Kind Code:
A3
Abstract:
[0083] The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
Inventors:
CIMBORA DANIEL M (US)
HEICHMAN KAREN (US)
BARTEL PAUL L (US)
HEICHMAN KAREN (US)
BARTEL PAUL L (US)
Application Number:
PCT/US2001/049198
Publication Date:
September 21, 2006
Filing Date:
December 21, 2001
Export Citation:
Assignee:
MYRIAD GENETICS INC (US)
International Classes:
A61K38/00; C07K2/00; C07K4/00; C07K5/00; C07K7/00; C07K14/00; C07K14/47; C07K16/00; C07K16/40; C07K17/00; C12N9/00; C12Q1/68; C12Q1/6883; G01N33/53; G01N33/68; G01N33/74
Other References:
XU J. ET AL.: "Review of the in vivo functions of the p160 steroid receptor coactivator family", MOLECULAR ENDOCRINOLOGY, vol. 17, no. 9, September 2003 (2003-09-01), pages 1681 - 1692
YANG C. ET AL.: "Two organochlorine pesticides, Toxaphene and Chlordane, are antagonists for Estrogen-related Receptor alpha-1", CANCER RES., vol. 59, 15 September 1999 (1999-09-15), pages 4519 - 4524
SCHMIDT S. ET AL.: "Multiple receptor interaction domains of GRIP1 function in synergy", NUCL. ACIDS RES., vol. 26, no. 5, 1998, pages 1191 - 1197
HONG H. ET AL.: "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors", PROC. NATL. ACAD. SCI. USA, vol. 93, May 1996 (1996-05-01), pages 4948 - 4952
CARAPETI M. ET AL.: "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia", BLOOD, vol. 91, no. 9, 1 May 1998 (1998-05-01), pages 3127 - 3133
YANG C. ET AL.: "Two organochlorine pesticides, Toxaphene and Chlordane, are antagonists for Estrogen-related Receptor alpha-1", CANCER RES., vol. 59, 15 September 1999 (1999-09-15), pages 4519 - 4524
SCHMIDT S. ET AL.: "Multiple receptor interaction domains of GRIP1 function in synergy", NUCL. ACIDS RES., vol. 26, no. 5, 1998, pages 1191 - 1197
HONG H. ET AL.: "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors", PROC. NATL. ACAD. SCI. USA, vol. 93, May 1996 (1996-05-01), pages 4948 - 4952
CARAPETI M. ET AL.: "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia", BLOOD, vol. 91, no. 9, 1 May 1998 (1998-05-01), pages 3127 - 3133
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