Title:
PROTEIN KINASE C IOTA
Document Type and Number:
WIPO Patent Application WO2005086909
Kind Code:
A3
Abstract:
The invention involves PKC? signaling. The invention provides, for example, transgenic animals, inhibitors of PKC? signaling, methods for inhibiting PKC? signaling, methods for identifying inhibitors of PKC? signaling, and methods for diagnosing cancer.
More Like This:
| WO/2005/079532 | METHODS AND COMPOSITIONS FOR ENHANCING RISC ACTIVITY IN VITRO AND IN VIVO |
| WO/2004/096995 | RECOMBINANT PLANT DICER |
| WO/2001/047950 | BASOLATERAL SORTING SIGNAL BASED ON SCF PEPTIDE AND INHIBITORS THEREOF |
Inventors:
MURRAY NICOLE RENEE (US)
STALLINGS-MANN MELODY LEE (US)
JAMIESON LEE (US)
FIELDS ALAN P (US)
STALLINGS-MANN MELODY LEE (US)
JAMIESON LEE (US)
FIELDS ALAN P (US)
Application Number:
PCT/US2005/007935
Publication Date:
January 19, 2006
Filing Date:
March 08, 2005
Export Citation:
Assignee:
MAYO FOUNDATION (US)
MURRAY NICOLE RENEE (US)
STALLINGS-MANN MELODY LEE (US)
JAMIESON LEE (US)
FIELDS ALAN P (US)
MURRAY NICOLE RENEE (US)
STALLINGS-MANN MELODY LEE (US)
JAMIESON LEE (US)
FIELDS ALAN P (US)
International Classes:
(IPC1-7): A01K67/00; G01N33/00
Other References:
HUANG ET AL.: "Inhibition of atypical PKC blocks ultraviolet induced AP-1 activation by specifically inhibitng ERKs activation.", MOL.CARCINOGENESIS, vol. 27, 2000, pages 65 - 75, XP002977567
HUANG ET AL.: "Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor bus is blocked by a doninant negative PKC", J. BIOL. CHEM., vol. 271, no. 49, 6 December 1996 (1996-12-06), pages 31262 - 31268, XP002993155
JANSEN ET. AL.: "Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilites of protein kinase C-alpha-delta and -epsilon transgeric mice.", INT. J. CANCER., vol. 93, 2001, pages 635 - 643, XP002993156
DATABASE CAPLUS SAKAI ET AL.: "Brain region specific and inducible gamma PKC-GFP transgenic mice as a tool for analysing gammaPKC functions in central vervous systems.", XP002993157
DATABASE BIOSIS 2001, CHOI ET AL.: "Expression of the PKC epsilon in the brain controls ethanol-drinking behavoir", XP002993158
DATABASE BIOSIS [online] 2001, SAKAI ET AL.: "Development of brain region specific and tet-regulated KC-GFP transgenic mice as tools for analysing PKC functions in cetral nervous system.", XP002993159
MURRAY ET AL.: "Protein kinase C iota is required for Ras transformation and colon carcinogenesis in vivo.", J.CELL BIOL., vol. 164, no. 6, 15 March 2004 (2004-03-15), pages 797 - 802, XP002993160
HUANG ET AL.: "Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor bus is blocked by a doninant negative PKC", J. BIOL. CHEM., vol. 271, no. 49, 6 December 1996 (1996-12-06), pages 31262 - 31268, XP002993155
JANSEN ET. AL.: "Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilites of protein kinase C-alpha-delta and -epsilon transgeric mice.", INT. J. CANCER., vol. 93, 2001, pages 635 - 643, XP002993156
DATABASE CAPLUS SAKAI ET AL.: "Brain region specific and inducible gamma PKC-GFP transgenic mice as a tool for analysing gammaPKC functions in central vervous systems.", XP002993157
DATABASE BIOSIS 2001, CHOI ET AL.: "Expression of the PKC epsilon in the brain controls ethanol-drinking behavoir", XP002993158
DATABASE BIOSIS [online] 2001, SAKAI ET AL.: "Development of brain region specific and tet-regulated KC-GFP transgenic mice as tools for analysing PKC functions in cetral nervous system.", XP002993159
MURRAY ET AL.: "Protein kinase C iota is required for Ras transformation and colon carcinogenesis in vivo.", J.CELL BIOL., vol. 164, no. 6, 15 March 2004 (2004-03-15), pages 797 - 802, XP002993160
Download PDF: