PROTEIN KINASE C MODULATORS, AND METHODS OF USE THEREOF

Title:

PROTEIN KINASE C MODULATORS, AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2004007445

Kind Code:

A3

Abstract:

One aspect of the present invention relates to amide-bearing substituted benzolactams, and individual stereoisomers thereof. A second aspect of the present invention relates to combinatorial libraries of the aforementioned amide-bearing substituted benzolactams, or individual stereoisomers thereof. Another aspect of the present invention relates to compositions, comprising an amide-bearing substituted benzolactam,and a pharmaceutically acceptable excipient. The present invention also encompasses methods of modulating the activity of PKC or enhancing the secretion of sAPPalpha or inducing hyperplasia in a mammal. Further, the present invention relates to methods of treating a mammal suffering from neuronal dysfunction, cognitive decline, neurodegeneration, stroke, Alzheimer's disease, Parkinson's disease, diabetes, heart disease, or cancer.

Inventors:

KOZIKOWSKI ALAN P (US)
BLUMBERG PETER M (US)
HENNINGS HENRY (US)
NOWAK IRENEUSZ (US)

Application Number:

PCT/US2003/022038

Publication Date:

September 10, 2004

Filing Date:

July 14, 2003

Export Citation:

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Assignee:

UNIV GEORGETOWN (US)
KOZIKOWSKI ALAN P (US)
BLUMBERG PETER M (US)
HENNINGS HENRY (US)
NOWAK IRENEUSZ (US)

International Classes:

C07D207/26; C07D245/06; (IPC1-7): C07D245/06; A61K31/40; A61K31/42; C07D207/12; C07D263/62

Foreign References:

US5962504A

1999-10-05

Other References:

MA ET AL: "General and Stereospecific Route to 9-Substituted, 8,9-Disubstituted, and 9,10-Disubstituted Analogues of Benzolactam-V8", J. ORG. CHEM., vol. 64, 1999, pages 6366 - 6373, XP002978713

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