Title:
PROTEIN KINASE INHIBITORS AND RELATED COMPOUNDS COMBINED WITH TAXOL
Document Type and Number:
WIPO Patent Application WO1994004541
Kind Code:
A3
Abstract:
This invention describes both known and novel compounds, some of which are protein kinase inhibitors, that may be combined with taxol type compounds. The combination of disclosed compounds plus taxol type compounds exhibits powerful synergistic effects and the combinations are useful in the treatment of cancer. The novel compounds and their synthesis are described. A compound of formula (I), above, is described wherein R1-R8 represent various substituents.
Inventors:
ABRAHAM IRENE (US)
ARISTOFF PAUL A (US)
SKULNICK HARVEY I (US)
ARISTOFF PAUL A (US)
SKULNICK HARVEY I (US)
Application Number:
PCT/US1993/007054
Publication Date:
June 09, 1994
Filing Date:
July 30, 1993
Export Citation:
Assignee:
UPJOHN CO (US)
International Classes:
A61K31/40; A61P35/00; C07D498/22; C07H9/06; C07H19/23; (IPC1-7): C07D498/22; A61K31/335; C07H19/23
Foreign References:
| EP0303697A1 | 1989-02-22 | |||
| EP0323171A2 | 1989-07-05 |
Other References:
CHEMICAL ABSTRACTS, vol. 111, no. 21, 20 November 1989, Columbus, Ohio, US; abstract no. 194456g, T. HIRATA ET AL: "Preparation of K-252 derivatives as protein kinase C inhibitors and formulations containing them" page 743;
CHEMICAL ABSTRACTS, vol. 107, no. 25, 21 December 1987, Columbus, Ohio, US; abstract no. 236750y, T. HIRATA ET AL: "Preparation of k-252 derivatives as protein kinase C inhibitors and drugs" page 796;
CHEMICAL ABSTRACTS, vol. 103, no. 21, 25 November 1985, Columbus, Ohio, US; abstract no. 171551e, T. TSURUO ET AL: "Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns" page 29;
R. L. FINE ET AL: "Phorbol esters induce multidrug resistance in human breast cancer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, no. 2, January 1988 (1988-01-01), WASHINGTON US, pages 582 - 586
CHEMICAL ABSTRACTS, vol. 107, no. 25, 21 December 1987, Columbus, Ohio, US; abstract no. 236750y, T. HIRATA ET AL: "Preparation of k-252 derivatives as protein kinase C inhibitors and drugs" page 796;
CHEMICAL ABSTRACTS, vol. 103, no. 21, 25 November 1985, Columbus, Ohio, US; abstract no. 171551e, T. TSURUO ET AL: "Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns" page 29;
R. L. FINE ET AL: "Phorbol esters induce multidrug resistance in human breast cancer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, no. 2, January 1988 (1988-01-01), WASHINGTON US, pages 582 - 586
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