Title:
PROTEIN LABELING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/125892
Kind Code:
A1
Abstract:
The present invention provides a compound that is represented by general formula (I) (In the formula, Z represents AA. Y
1 represents N or CR1, Y2 represents N or CR2, Y3 represents N or CR3, and Y4 represents N or CR4. One of R1-R4 in these formulas represents a group represented by the belowmentioned formula -(L1)n1-Lg (In the formula, L1 represents a divalent linking group, n1 represents 0 or 1, and Lg represents a protein ligand), and the other three groups out of R1-R4 represent hydrogen atoms or substituent groups, and one of R5-R9 represents a group represented by the belowmentioned formula -(L2)n2-pr (In the formula, L2 represents a divalent linking group, n2 represents 0 or 1, and pr represents a probe), and the other 4 groups out of R5-R9 represent hydrogen atoms or substituent groups), or a salt thereof.
Inventors:
HAMACHI ITARU (JP)
MATSUO KAZUYA (JP)
MASUDA MARIE (JP)
NISHIKAWA YUKI (JP)
MATSUO KAZUYA (JP)
MASUDA MARIE (JP)
NISHIKAWA YUKI (JP)
Application Number:
PCT/JP2015/054685
Publication Date:
August 27, 2015
Filing Date:
February 19, 2015
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07D213/82; C07C309/77; C07C309/89; C07D213/89; C07D239/86; C07D239/94; C07D311/16; C07D311/80; C07D401/12; C07D405/12; C07K1/13; G01N21/64; G01N33/15; G01N33/50; G01N33/533; G01N33/542; G01N33/566
Other References:
DATABASE REGISTRY retrieved from STN Database accession no. RN 857435-48-4
DATABASE REGISTRY 1 July 2013 (2013-07-01), retrieved from STN Database accession no. 1442631-53-9
DATABASE REGISTRY 9 November 2011 (2011-11-09), retrieved from STN Database accession no. RN 1343408-24-1
DATABASE REGISTRY 5 April 1998 (1998-04-05), retrieved from STN Database accession no. 203639-82-1
KAZUYA MATSUO ET AL.: "3 G4-26 Ligand Shikogata Kagaku no Shintenkai (1) N-Sulfonyl Pyridone Kagaku ni yoru Saibonai Tanpakushitsu no Tokuiteki Sulfonyl-ka", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 94 SHUNKI NENKAI (2014) KOEN YOKOSHU IV, 12 March 2014 (2014-03-12), pages 1432
MARIE MASUDA ET AL.: "3 G4-28 Ligand Shikogata Kagaku no Shintenkai (2) N-Sulfonyl Pyridone Kagaku ni yoru Saibomaku Tanpakushitsu no Sentakuteki Label-ka", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 94 SHUNKI NENKAI (2014) KOEN YOKOSHU IV, 12 March 2014 (2014-03-12), pages 1432
OTSUKI, S ET AL.: "Chemical tagging of a drug target using 5-sulfonyl tetrazole", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 6, 2013, pages 1608 - 1611, XP028986046, ISSN: 0960-894x
FUJISHIMA, S. ET AL.: "Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane- Bound Proteins on Liver Cells", J. AM. CHEM. SOC., vol. 134, no. 9, 2012, pages 3961 - 3964, XP055221495, ISSN: 0002-7863
HUGHES, C. C. ET AL.: "Marinopyrrole A Target Elucidation by Acyl Dye Transfer", J. AM. CHEM. SOC., vol. 131, no. 34, 2009, pages 12094 - 12096, XP055221497, ISSN: 0002-7863
DATABASE REGISTRY 1 July 2013 (2013-07-01), retrieved from STN Database accession no. 1442631-53-9
DATABASE REGISTRY 9 November 2011 (2011-11-09), retrieved from STN Database accession no. RN 1343408-24-1
DATABASE REGISTRY 5 April 1998 (1998-04-05), retrieved from STN Database accession no. 203639-82-1
KAZUYA MATSUO ET AL.: "3 G4-26 Ligand Shikogata Kagaku no Shintenkai (1) N-Sulfonyl Pyridone Kagaku ni yoru Saibonai Tanpakushitsu no Tokuiteki Sulfonyl-ka", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 94 SHUNKI NENKAI (2014) KOEN YOKOSHU IV, 12 March 2014 (2014-03-12), pages 1432
MARIE MASUDA ET AL.: "3 G4-28 Ligand Shikogata Kagaku no Shintenkai (2) N-Sulfonyl Pyridone Kagaku ni yoru Saibomaku Tanpakushitsu no Sentakuteki Label-ka", CSJ: THE CHEMICAL SOCIETY OF JAPAN DAI 94 SHUNKI NENKAI (2014) KOEN YOKOSHU IV, 12 March 2014 (2014-03-12), pages 1432
OTSUKI, S ET AL.: "Chemical tagging of a drug target using 5-sulfonyl tetrazole", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 6, 2013, pages 1608 - 1611, XP028986046, ISSN: 0960-894x
FUJISHIMA, S. ET AL.: "Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane- Bound Proteins on Liver Cells", J. AM. CHEM. SOC., vol. 134, no. 9, 2012, pages 3961 - 3964, XP055221495, ISSN: 0002-7863
HUGHES, C. C. ET AL.: "Marinopyrrole A Target Elucidation by Acyl Dye Transfer", J. AM. CHEM. SOC., vol. 131, no. 34, 2009, pages 12094 - 12096, XP055221497, ISSN: 0002-7863
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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