Title:
PROTEIN MODIFIER PRODUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2005/054205
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a protein modifier production inhibitor capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent. [MEANS FOR SOLVING PROBLEMS] There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is a substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simultaneously hydrogen atoms].
Inventors:
MIYATA TOSHIO (JP)
KUROKAWA KIYOSHI (JP)
KUROKAWA KIYOSHI (JP)
Application Number:
PCT/JP2004/018038
Publication Date:
June 16, 2005
Filing Date:
December 03, 2004
Export Citation:
Assignee:
UNIV TOKAI (JP)
MIYATA TOSHIO (JP)
KUROKAWA KIYOSHI (JP)
MIYATA TOSHIO (JP)
KUROKAWA KIYOSHI (JP)
International Classes:
C07D491/04; (IPC1-7): C07D231/22; C07D231/24; C07D231/46; C07D231/50; C07D231/52; C07D495/10; C07D403/12; C07D417/12; C07D405/06; C07D401/06; C07D403/04; C07D409/06; C07D417/04; C07D409/04; C07D491/048; C07D487/10; A61K31/4152; A61K31/4162; A61K31/4155; A61K31/427; A61K31/4709; A61K31/433; A61K31/4439; A61K31/4355; A61K31/416; A61P13/12; A61P3/10; A61P25/00; A61P27/02; A61P27/12; A61P9/10; A61P13/00; A61P25/28; A61P25/16; A61P29/00; A61P19/02; A61P17/00; A61P7/08; A61P9/00; A61P43/00; A61P39/00; A61P39/02
Domestic Patent References:
| WO2003024446A1 | 2003-03-27 |
Foreign References:
| JPH06287179A | 1994-10-11 | |||
| US20030086916A1 | 2003-05-08 | |||
| JP2003081830A | 2003-03-19 | |||
| JPH03215426A | 1991-09-20 | |||
| JPH0725765A | 1995-01-27 | |||
| JPH02229168A | 1990-09-11 | |||
| JPH02229169A | 1990-09-11 | |||
| JP2004300153A | 2004-10-28 |
Other References:
MIYATA T. ET AL: "Alterrations in nonenzymatic biochemistry in uremia: Origin and significance of "carbonyl stress" in long-term uremic complications", KIDNEY INTERNATIONAL, vol. 55, 1999, pages 389 - 399, XP002986904
See also references of EP 1693369A4
See also references of EP 1693369A4
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 01, JP)
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