Title:
PROTEIN PHOSPHATASE 2A INHIBITORS TO INHIBIT HOST-CELL MEDIATED VIRAL REPLICATION
Document Type and Number:
WIPO Patent Application WO2001095896
Kind Code:
A3
Abstract:
Methods are provided for inhibiting or suppressing viral replication in an infected host cell. More specifically, methods are provided for inhibiting or suppressing viral replication in an infected host cell by administering compounds that inhibit cellular protein phosphatase 2A. Such methods are advantageous for treating viral infections such human immunodeficiency virus infections.
Inventors:
MARKOVITZ DAVID M (US)
FAULKNER NEIL (US)
LANE BRIAN (US)
FAULKNER NEIL (US)
LANE BRIAN (US)
Application Number:
PCT/US2001/018960
Publication Date:
July 25, 2002
Filing Date:
June 12, 2001
Export Citation:
Assignee:
UNIV MICHIGAN (US)
MARKOVITZ DAVID M (US)
FAULKNER NEIL (US)
LANE BRIAN (US)
MARKOVITZ DAVID M (US)
FAULKNER NEIL (US)
LANE BRIAN (US)
International Classes:
A61K31/35; A61K31/366; A61P31/12; (IPC1-7): A61K31/35; A61K31/366; A61P31/12
Domestic Patent References:
| WO1996010402A1 | 1996-04-11 |
Other References:
GARCIA ET AL: "PP2A: A DEFINITE PLAYER IN VIRAL AND PARASITIC REGULATION", MICROBES AND INFECTION, vol. 2, no. 4, April 2000 (2000-04-01), pages 401 - 407, XP002190319
VLACH ET AL: "INDUCTION OF SP1 PHOSPHORYLATION AND NF-KB-INDEPENDENT HIV PROMOTER DOMAIN ACTIVITY IN T LYMPHOCYTES STIMULATED BY OKADAIC ACID", VIROLOGY, vol. 208, 1995, pages 753 - 761, XP002190320
LIN ET AL: "PP2A IS REQUIRED FOR THE INITIATION OF CHROMOSOMAL DNA REPLICATION", PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 14693 - 14698, XP002190321
VLACH ET AL: "INDUCTION OF SP1 PHOSPHORYLATION AND NF-KB-INDEPENDENT HIV PROMOTER DOMAIN ACTIVITY IN T LYMPHOCYTES STIMULATED BY OKADAIC ACID", VIROLOGY, vol. 208, 1995, pages 753 - 761, XP002190320
LIN ET AL: "PP2A IS REQUIRED FOR THE INITIATION OF CHROMOSOMAL DNA REPLICATION", PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 14693 - 14698, XP002190321
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