Title:
PROTEIN REGULATOR-TARGETED COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228576
Kind Code:
A1
Abstract:
A protein regulator-targeted compound and an application thereof. The compound is a compound represented by formula Ia, Ib or Ic. The compound has a good inhibition effect and protein degradation effect on a KRAS_G12D mutant.
Inventors:
ZHANG CHAOXIN (CN)
MAO HAIBIN (CN)
XIA GUANGXIN (CN)
DENG WEI (CN)
MA XING (CN)
FU JIANMIN (CN)
WANG XUESONG (CN)
FU YUHONG (CN)
KE YING (CN)
WANG QIAN (CN)
MAO HAIBIN (CN)
XIA GUANGXIN (CN)
DENG WEI (CN)
MA XING (CN)
FU JIANMIN (CN)
WANG XUESONG (CN)
FU YUHONG (CN)
KE YING (CN)
WANG QIAN (CN)
Application Number:
PCT/CN2022/090813
Publication Date:
November 03, 2022
Filing Date:
April 29, 2022
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D401/14; A61K31/427; A61K31/506; A61K31/517; A61P35/00; C07D403/12; C07D417/04; C07D417/12; C07D417/14
Domestic Patent References:
| WO2021207172A1 | 2021-10-14 | |||
| WO2021051034A1 | 2021-03-18 | |||
| WO2021041671A1 | 2021-03-04 |
Foreign References:
| CN112218859A | 2021-01-12 | |||
| US20180015087A1 | 2018-01-18 | |||
| CN102887895A | 2013-01-23 | |||
| CN103588792A | 2014-02-19 |
Other References:
KARGBO ROBERT B.: "PROTAC-Mediated Degradation of KRAS Protein for Anticancer Therapeutics", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 11, no. 1, 9 January 2020 (2020-01-09), US , pages 5 - 6, XP055982838, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00584
BOND MICHAEL J., CHU LING, NALAWANSHA DHANUSHA A., LI KE, CREWS CRAIG M.: "Targeted Degradation of Oncogenic KRAS G12C by VHL-Recruiting PROTACs", ACS CENTRAL SCIENCE, vol. 6, no. 8, 26 August 2020 (2020-08-26), pages 1367 - 1375, XP055866207, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c00411
BOND MICHAEL J., CHU LING, NALAWANSHA DHANUSHA A., LI KE, CREWS CRAIG M.: "Targeted Degradation of Oncogenic KRAS G12C by VHL-Recruiting PROTACs", ACS CENTRAL SCIENCE, vol. 6, no. 8, 26 August 2020 (2020-08-26), pages 1367 - 1375, XP055866207, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c00411
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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