Title:
PROTEIN SUBSTRATE TO BIND GROWTH FACTOR
Document Type and Number:
WIPO Patent Application WO/2022/131809
Kind Code:
A1
Abstract:
Protein substrates are provided comprising integrin binding motif and growth factor (GF) binding peptide motif that enable binding to and activation of both a growth factor receptor and an integrin, simultaneously or selectively. The substrate proteins may be in the form of a mussel adhesive protein where extracellular matrix (ECM) protein derived integrin binding peptide motifs and GF binding peptide motifs are recombinantly incorporated into the mussel adhesive protein. Also provided are use of the protein substrate for regulating cellular behavior including cell adhesion, migration, or proliferation which are essential process in bioprocess, wound healing, tissue engineering, and therapeutic application. In other embodiments, the present invention provides a method and composition of stabilizing and protecting a growth factor from protease digestion or internalization into cells (or cellular uptake) in order to maintain the persistent and durable function of growth factors.
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Inventors:
LEE SANG JAE (KR)
HONG BONG JIN (KR)
PARK MIN CHUL (KR)
HONG BONG JIN (KR)
PARK MIN CHUL (KR)
Application Number:
PCT/KR2021/019159
Publication Date:
June 23, 2022
Filing Date:
December 16, 2021
Export Citation:
Assignee:
TME THERAPEUTICS CO LTD (KR)
International Classes:
C07K14/435; C07K14/78; C12N5/00
Domestic Patent References:
| WO2008150101A2 | 2008-12-11 |
Foreign References:
| US20160355780A1 | 2016-12-08 | |||
| EP3202781A1 | 2017-08-09 | |||
| US20190382719A1 | 2019-12-19 | |||
| US20150252148A1 | 2015-09-10 |
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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