PROTEIN TYROSINE KINASE ENZYME INHIBITORS

Title:

PROTEIN TYROSINE KINASE ENZYME INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005028443

Kind Code:

A3

Abstract:

This invention provides compounds of formula 1, having the structure wherein R1, R2, R3 are described within the specification.

Inventors:

WISSNER ALLAN (US)
RABINDRAN SRIDHAR KRISHNA (US)
TSOU HWEI-RU (US)

Application Number:

PCT/US2004/030220

Publication Date:

May 06, 2005

Filing Date:

September 15, 2004

Export Citation:

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Assignee:

WYETH CORP (US)
WISSNER ALLAN (US)
RABINDRAN SRIDHAR KRISHNA (US)
TSOU HWEI-RU (US)

International Classes:

C07D215/54; C07D401/12; C07D401/14; C07D405/12; C07D409/12; C07D413/12; C07D417/12; (IPC1-7): C07D215/54; A61K31/4709; A61K31/517; C07D401/12; C07D401/14; C07D417/12

Domestic Patent References:

WO2003050090A1	2003-06-19
WO1998043960A1	1998-10-08
WO2004096224A2	2004-11-11

Foreign References:

US6288082B1

2001-09-11

Other References:

RABINDRAN, SRIDHAR K. ET AL: "Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase", CANCER RESEARCH , 64(11), 3958-3965 CODEN: CNREA8; ISSN: 0008-5472, 2004, XP002318446

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