PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

WIPO Patent Application WO2006055525

A3

The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

BLASKOVICH MARK A (AU)
BAUGHMAN TED (US)
LITTLE THOMAS (US)
PATT WILLIAM (US)
QABAR MAHER (US)
SCHULTZ LAURI (US)
HONG FENG (US)
NAGULA GANGADHAR (US)
GAGE JENNIFER LYNN (US)
HOWBERT JAMES JEFFRY (US)

PCT/US2005/041269

September 21, 2006

November 15, 2005

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CEPTYR INC (US)
BLASKOVICH MARK A (AU)
BAUGHMAN TED (US)
LITTLE THOMAS (US)
PATT WILLIAM (US)
QABAR MAHER (US)
SCHULTZ LAURI (US)
HONG FENG (US)
NAGULA GANGADHAR (US)
GAGE JENNIFER LYNN (US)
HOWBERT JAMES JEFFRY (US)

A61K31/66; C07F9/02

DATABASE CAS [online] BUCHANAN ET AL.: "Preparation of Heterocyclic Phosphotyrosine Derivatives as SH-2mediated Signal Transduction Inhibitors", XP003002333, Database accession no. (131:257875)
See also references of EP 1812012A4

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