Title:
PROTEINS ASSOCIATED WITH CELL DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO2001019860
Kind Code:
A3
Abstract:
The invention provides human proteins involved in cell differentiation (CDIFF) and polynucleotides which identify and encode CDIFF. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CDIFF.
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Inventors:
TANG Y TOM (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA (US)
LAL PREETI (US)
SHAH PURVI (US)
AZIMZAI YALDA (US)
BAUGHN MARIAH R (US)
LU DYUNG AINA M (US)
BANDMAN OLGA (US)
SHIH LEO L (US)
PATTERSON CHANDRA (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA (US)
LAL PREETI (US)
SHAH PURVI (US)
AZIMZAI YALDA (US)
BAUGHN MARIAH R (US)
LU DYUNG AINA M (US)
BANDMAN OLGA (US)
SHIH LEO L (US)
PATTERSON CHANDRA (US)
Application Number:
PCT/US2000/025435
Publication Date:
January 24, 2002
Filing Date:
September 14, 2000
Export Citation:
Assignee:
INCYTE GENOMICS INC (US)
TANG Y TOM (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA (US)
LAL PREETI (US)
SHAH PURVI (US)
AZIMZAI YALDA (US)
BAUGHN MARIAH R (US)
LU DYUNG AINA M (US)
BANDMAN OLGA (US)
SHIH LEO L (US)
PATTERSON CHANDRA (US)
TANG Y TOM (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA (US)
LAL PREETI (US)
SHAH PURVI (US)
AZIMZAI YALDA (US)
BAUGHN MARIAH R (US)
LU DYUNG AINA M (US)
BANDMAN OLGA (US)
SHIH LEO L (US)
PATTERSON CHANDRA (US)
International Classes:
G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/16; A61P3/12; A61P5/00; A61P5/14; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P27/16; A61P29/00; A61P35/00; A61P35/02; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; A01K67/027; A61K38/17; A61P43/00; C07K14/47; C07K16/18; C12N5/10; C12N15/63; C12P21/00; C12Q1/68; G01N33/53
Domestic Patent References:
| WO1998041634A1 | 1998-09-24 | |||
| WO2000058473A2 | 2000-10-05 |
Foreign References:
| US5739009A | 1998-04-14 |
Other References:
LIU ET AL.: "Isolation of 10 differentially expressed cDNAs in differentiated Nuro2a cells induced through controlled expression of the GD3 synthase gene", JOURNAL OF NEUROCHEMISTRY, vol. 72, 1999, pages 1781 - 1790, XP000992245
ABDELHAK S ET AL: "A HUMAN HOMOLOGUE OF THE DROSOPHILA EYES ABSENT GENE UNDERLIES BRANCHIO-OTO-RENAL (BOR) SYNDROME AND IDENTIFIES A NOVEL GENE FAMILY", NATURE GENETICS,US,NEW YORK, NY, vol. 15, no. 2, 1 February 1997 (1997-02-01), pages 157 - 164, XP002071634, ISSN: 1061-4036
HOLMES G P ET AL: "DISCTINCT BUT OVERLAPPING EXPRESSION PATTERNS OF TWO VERTEBRATE SLIT HOMOLOGS IMPLIES FUNCTIONAL ROLES IN CNS DEVELOPMENT AND ORGANOGENESIS", MECHANISMS OF DEVELOPMENT,ELSEVIER SCIENCE IRELAND LTD,IE, vol. 79, 1998, pages 57 - 72, XP000912208, ISSN: 0925-4773
NCI-CGAP: "wg81e08.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens cDNA clone IMAGE:2371526 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 30 June 1999 (1999-06-30), HEIDELBERG DE, XP002163337
NCI-CGAP: "wg81f07.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens cDNA clone IMAGE:2371525 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 30 June 1999 (1999-06-30), HEIDELBERG DE, XP002163338
HILLIER ET AL.: "au43h04.y1 Schneider fetal brain 00004 Homo sapiens cDNA clone IMAGE:2517559 5' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 12 July 1999 (1999-07-12), HEIDELBERG DE, XP002163339
HILLIER ET AL.: "au43h04.y1 Schneider fetal brain 00004 Homo sapiens cDNA clone IMAGE:2517559 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 12 July 1999 (1999-07-12), HEIDELBERG DE, XP002163340
FUJIWARA, T.: "Human fetal brain cDNA 5'-end GEN-413E12", EMBL SEQUENCE DATABASE, 29 September 1996 (1996-09-29), HEIDELBERG DE, XP002163341
ABDELHAK S ET AL: "A HUMAN HOMOLOGUE OF THE DROSOPHILA EYES ABSENT GENE UNDERLIES BRANCHIO-OTO-RENAL (BOR) SYNDROME AND IDENTIFIES A NOVEL GENE FAMILY", NATURE GENETICS,US,NEW YORK, NY, vol. 15, no. 2, 1 February 1997 (1997-02-01), pages 157 - 164, XP002071634, ISSN: 1061-4036
HOLMES G P ET AL: "DISCTINCT BUT OVERLAPPING EXPRESSION PATTERNS OF TWO VERTEBRATE SLIT HOMOLOGS IMPLIES FUNCTIONAL ROLES IN CNS DEVELOPMENT AND ORGANOGENESIS", MECHANISMS OF DEVELOPMENT,ELSEVIER SCIENCE IRELAND LTD,IE, vol. 79, 1998, pages 57 - 72, XP000912208, ISSN: 0925-4773
NCI-CGAP: "wg81e08.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens cDNA clone IMAGE:2371526 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 30 June 1999 (1999-06-30), HEIDELBERG DE, XP002163337
NCI-CGAP: "wg81f07.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens cDNA clone IMAGE:2371525 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 30 June 1999 (1999-06-30), HEIDELBERG DE, XP002163338
HILLIER ET AL.: "au43h04.y1 Schneider fetal brain 00004 Homo sapiens cDNA clone IMAGE:2517559 5' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 12 July 1999 (1999-07-12), HEIDELBERG DE, XP002163339
HILLIER ET AL.: "au43h04.y1 Schneider fetal brain 00004 Homo sapiens cDNA clone IMAGE:2517559 3' similar to TR:O88741 O88741 GANGLIOSIDE-INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1. ;, mRNA sequence", EMBL SEQUENCE DATABASE, 12 July 1999 (1999-07-12), HEIDELBERG DE, XP002163340
FUJIWARA, T.: "Human fetal brain cDNA 5'-end GEN-413E12", EMBL SEQUENCE DATABASE, 29 September 1996 (1996-09-29), HEIDELBERG DE, XP002163341
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