Title:
PROTEINS HAVING PNEUMOCOCCAL CAPSULE DEGRADING ACTIVITY AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2019/036373
Kind Code:
A3
Abstract:
Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof.
Inventors:
AVCI FIKRI (US)
MIDDLETON DUSTIN (US)
PASCHALL AMY (US)
MIDDLETON DUSTIN (US)
PASCHALL AMY (US)
Application Number:
PCT/US2018/046521
Publication Date:
March 19, 2020
Filing Date:
August 13, 2018
Export Citation:
Assignee:
UNIV GEORGIA (US)
International Classes:
A01K67/027; A61K31/7088; A61K35/74
Foreign References:
| US20160115466A1 | 2016-04-28 |
Other References:
SICKLES, GRACE AND SHAW, MYRTLE.: "A systematic study of microorganisms wich decompose the specific carbohydrates of the pneumococcus", J.BACTERIOL., vol. 28, no. 4, 1934, pages 415 - 431, XP055681634
DATABASE Uniprot KB 20 January 2016 (2016-01-20), "Functional overlap of the arabidopsis leaf and root microbiotas ( amino acids 6-1460)", XP009519747, Database accession no. A0A0Q9N3M1_9BACL
DATABASE Uniprot KB 20 January 2016 (2016-01-20), "Functional overlap of the arabidopsis leaf and root microbiotas ( amino acids 6-1460)", XP009519747, Database accession no. A0A0Q9N3M1_9BACL
Attorney, Agent or Firm:
PROVENCE, David, L. (US)
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