Title:
PSEUDOTYPED RETROVIRAL VECTOR SYSTEM
Document Type and Number:
WIPO Patent Application WO2003025191
Kind Code:
A3
Abstract:
The present invention relates to a retrovial vector system comprising a therapeutic gene wherein said retroviral vector system is pseudotyped with at least part of a heterologous envelope protein or a mutant, variant or homologue thereof and wherein said therapeutic gene is downstream of an internal promoter.
Inventors:
SLADE ANDREW (GB)
KINGSMAN SUSAN (GB)
KINGSMAN SUSAN (GB)
Application Number:
PCT/GB2002/004323
Publication Date:
September 18, 2003
Filing Date:
September 23, 2002
Export Citation:
Assignee:
OXFORD BIOMEDICA LTD (GB)
SLADE ANDREW (GB)
KINGSMAN SUSAN (GB)
SLADE ANDREW (GB)
KINGSMAN SUSAN (GB)
International Classes:
C12N15/09; A61K35/76; A61K48/00; A61P35/00; C12N5/10; C12N7/00; C12N9/02; C12N15/867; (IPC1-7): C12N15/867; A61K38/44; A61K48/00; C12N5/10; C12N9/02; C12N15/86
Domestic Patent References:
| WO2001066150A2 | 2001-09-13 | |||
| WO1996030533A1 | 1996-10-03 | |||
| WO1997035994A2 | 1997-10-02 | |||
| WO1996004789A1 | 1996-02-22 |
Foreign References:
| US6207648B1 | 2001-03-27 |
Other References:
KELLY P ET AL: "Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 96, no. 4, 15 August 2000 (2000-08-15), pages 1206 - 1214, XP002190047, ISSN: 0006-4971
MILLER N ET AL: "TARGETED VECTORS FOR GENE THERAPY", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 9, no. 2, 1 February 1995 (1995-02-01), pages 190 - 199, XP000616414, ISSN: 0892-6638
SALMONS B ET AL: "CONSTRUCTION OF RETROVIRAL VECTORS FOR TARGETED DELIVERY AND EXPRESSION OF THERAPEUTIC GENES", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 9, no. SUPPL 1, 1 October 1995 (1995-10-01), pages S53 - S60, XP000575934, ISSN: 0887-6924
MILLER N ET AL: "TARGETED VECTORS FOR GENE THERAPY", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 9, no. 2, 1 February 1995 (1995-02-01), pages 190 - 199, XP000616414, ISSN: 0892-6638
SALMONS B ET AL: "CONSTRUCTION OF RETROVIRAL VECTORS FOR TARGETED DELIVERY AND EXPRESSION OF THERAPEUTIC GENES", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 9, no. SUPPL 1, 1 October 1995 (1995-10-01), pages S53 - S60, XP000575934, ISSN: 0887-6924
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