PSYCHOACTIVE COMPOUND ASSOCIATED MARKERS AND METHOD OF USE THEREOF

WIPO Patent Application WO2004088274

A3

Disclosed are methods of identifying psychoactive agents, e.g., anti-depressant, anti-psychotic or opioid compound, using differential gene expression.

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GUNTHER ERIK (US)
STONE DAVID J (US)
GERWIEN ROBERT W (US)

PCT/US2004/009042

February 09, 2006

March 26, 2004

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CURAGEN CORP (US)
GUNTHER ERIK (US)
STONE DAVID J (US)
GERWIEN ROBERT W (US)

C12Q1/68; G01N33/50; G01N33/94; G01N; (IPC1-7): G01N33/53; A01N37/18; A61K38/00; C07H21/02; C07H21/04; C07K14/00; C07K16/00; C07K17/00; C12P21/06; G01N33/542

BUNNEY ET AL: "Microarray technology: A review of new strategies to discover candidate vulnerability genes in psychiatric disorders", AM J PSYCHIATRY, vol. 160, no. 4, 2003, pages 657 - 666, XP002993289
AMBROSIO ET AL: "The neurobiology of cannabinoid dependence: sex differences and potential interactions between cannabinoid and opioid systems", LIFE SCI., vol. 65, no. 6-7, 1999, pages 687 - 694, XP002993290
BERGMAN ET AL: "Agonist efficacy, drug dependence, and medications development: preclinical evaluation of opioid, dopaminergic, and GABA-ergic ligands", PSYCHOPHARMACOLOGY, vol. 153, 2000, pages 67 - 84, XP002993291
HUANG Y. ET L: "Integrin-linked kinase and associated proteins (Review)", INT J MOL MED, vol. 3, 1999, pages 563 - 572, XP009041608

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