Title:
PULMONARY DELIVERY IN TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO2002024158
Kind Code:
A3
Abstract:
A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. Particles that include the drug can be employed. Preferred particles have a tap density of less than about 0.4 g/cm<3>. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others. The drug is administered at a dose which is at least about two-fold less than the dose required by oral administration.
Inventors:
BARTUS RAYMOND T (US)
EMERICH DWAINE E (US)
EMERICH DWAINE E (US)
Application Number:
PCT/US2001/029311
Publication Date:
September 19, 2002
Filing Date:
September 19, 2001
Export Citation:
Assignee:
ADVANCED INHALATION RES INC (US)
BARTUS RAYMOND T (US)
EMERICH DWAINE E (US)
BARTUS RAYMOND T (US)
EMERICH DWAINE E (US)
International Classes:
A61K9/00; A61K9/14; A61K9/12; A61K9/72; A61K31/192; A61K31/198; A61K31/473; A61K31/517; A61K47/02; A61K47/06; A61K47/12; A61K47/18; A61L9/04; A61P25/00; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; (IPC1-7): A61K9/00
Domestic Patent References:
| WO1998031346A1 | 1998-07-23 | |||
| WO2000072827A2 | 2000-12-07 | |||
| WO2001095874A2 | 2001-12-20 |
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