Title:
PURIFICATION METHOD FOR 4"-(S)-METHYLAMINO ABAMECTIN B2A BENZOATE
Document Type and Number:
WIPO Patent Application WO/2022/134385
Kind Code:
A1
Abstract:
The present invention relates to the technical field of agricultural chemicals and preparation. Specifically, disclosed is a purification method for 4"-(s)-methylamino abamectin B2a benzoate. The purification method comprises the following steps: adding a crude product of methylamino abamectin B2a/2b benzoate to methyl tert-butyl ether, heating and dissolving, dropwise adding a mixed solution of tert-butanol and n-butyl ether, cooling and filtering after the dropwise adding, and cooling and crystallizing an obtained filtrate to obtain a product of 4"-(s)-methylamino abamectin B2a benzoate. According to the purification method provided by the present invention, by selecting the mixed solution of methyl tert-butyl ether, tert-butanol and n-butyl ether as a crystallization solvent, and in coordination with twice cooling and crystallization, the product of 4"-(s)-methylamino abamectin B2a benzoate having S-configured methylamino at bit 4" and having a content of 98% or more is obtained, thereby facilitating improvement of the insecticidal activity of related preparations, and achieving a wide application prospect.
Inventors:
WANG BO (CN)
TIAN XUEFANG (CN)
GAO YONGMIN (CN)
ZHANG BO (CN)
ZHANG LIRONG (CN)
LI ZHIFENG (CN)
LI LIHUA (CN)
FAN ZHAOHUI (CN)
JIA CHENGGUO (CN)
TIAN XUEFANG (CN)
GAO YONGMIN (CN)
ZHANG BO (CN)
ZHANG LIRONG (CN)
LI ZHIFENG (CN)
LI LIHUA (CN)
FAN ZHAOHUI (CN)
JIA CHENGGUO (CN)
Application Number:
PCT/CN2021/086469
Publication Date:
June 30, 2022
Filing Date:
April 12, 2021
Export Citation:
Assignee:
HEBEI VEYONG BIO CHEM CO LTD (CN)
International Classes:
C07H1/06; C07C51/43; C07C63/08; C07H17/08
Foreign References:
| CN112707939A | 2021-04-27 | |||
| CN103497226A | 2014-01-08 | |||
| CN104876990A | 2015-09-02 | |||
| CN108191935A | 2018-06-22 | |||
| CN106243174A | 2016-12-21 | |||
| EP0351923A2 | 1990-01-24 |
Attorney, Agent or Firm:
HEBEI GUOWEIZHIYUAN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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