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Title:
PURIFICATION METHOD FOR POLYETHYLENE GLYCOL HAVING A SINGLE AMINO GROUP
Document Type and Number:
WIPO Patent Application WO/2014/157117
Kind Code:
A1
Abstract:
Provided is a method for purification of polyethylene glycol compound having a single amino group, on an industrial scale with good efficiency and purity, and without generating waste materials such as adsorbents and ion-exchange resins. An aqueous solution of the polyethylene glycol is prepared, the aqueous solution having pH of 1-5. This aqueous solution and a mixed organic solvent are mixed together at 10ºC or higher but not more than 55ºC, bringing about layer separation into an organic layer and an aqueous layer. The proportion of an organic solvent I in the mixed organic solvent is 25-65 mass%, and the proportion of an organic solvent II is 75-35 mass%. The organic solvent I is selected from aromatic hydrocarbon based solvent having a total carbon number of 8 or less and esterified compound solvents devoid of hetero atoms and having a total carbon number of 5 or less, while the organic solvent II is a halogenated hydrocarbon based solvent. The mixture ratio of the organic solvent I with respect to the organic solvent II (organic solvent I/ organic solvent II) Y, the temperature T (ºC), and the molecular weight M of the polyethylene glycol compound satisfy the following relationship. 1.9 × 10-6M + 0.09 ≤ Y - 0.015T ≤ -1.4 X 10-6M + 0.44

Inventors:
YOSHIOKA HIROKI (JP)
KIMURA SHINGO (JP)
HIRAI MIDORI (JP)
Application Number:
PCT/JP2014/058139
Publication Date:
October 02, 2014
Filing Date:
March 24, 2014
Export Citation:
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Assignee:
NOF CORP (JP)
International Classes:
C08G65/30
Domestic Patent References:
WO2006006511A12006-01-19
WO2005095494A12005-10-13
WO2006057778A22006-06-01
Foreign References:
JPH09169683A1997-06-30
JPH08165343A1996-06-25
JPH08165343A1996-06-25
JP2010254978A2010-11-11
JP2010254981A2010-11-11
US20090000834A12009-01-01
JP2004197077A2004-07-15
JPH09504299A1997-04-28
JPH01165343A1989-06-29
Other References:
See also references of EP 2980115A4
Attorney, Agent or Firm:
Shin-Ei Patent Firm, P. C. (JP)
Patent business corporation Shin-Ei Patent Firm (JP)
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