Title:
PURIFIED THERAPEUTIC NANOPARTICLES AND PREPARATION METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/000653
Kind Code:
A1
Abstract:
Purified therapeutic nanoparticles are provided herein. Such nanoparticles comprise an active pharmaceutical ingredient and human serum albumin, wherein the weight ratio of human serum albumin to the active ingredient in the therapeutic nanoparticles is from 0.01:1 to 1:1, and wherein the nanoparticles are substantially free of free human serum albumin that is not incorporated in the nanoparticles. The present disclosure also provides pharmaceutical compositions that comprise the purified therapeutic nanoparticles and are also substantially free of free human serum albumin. Methods for preparing and using the purified therapeutic nanoparticles and compositions thereof are also provided.
Inventors:
LI CHUNLEI (CN)
LI YANHUI (CN)
LIANG MIN (CN)
WANG CAIXIA (CN)
WANG YAJUAN (CN)
WANG SHIXIA (CN)
CHEN DONGJIAN (CN)
LI YONGFENG (CN)
LI YANHUI (CN)
LIANG MIN (CN)
WANG CAIXIA (CN)
WANG YAJUAN (CN)
WANG SHIXIA (CN)
CHEN DONGJIAN (CN)
LI YONGFENG (CN)
Application Number:
PCT/CN2015/083255
Publication Date:
January 07, 2016
Filing Date:
July 03, 2015
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUAN (CN)
International Classes:
A61K9/14; A61K9/19; A61K45/00; A61K47/42; A61P35/00
Domestic Patent References:
| WO2011153010A1 | 2011-12-08 |
Foreign References:
| CN103221042A | 2013-07-24 | |||
| CN102988996A | 2013-03-27 | |||
| CN1736489A | 2006-02-22 |
Other References:
LI CHUNLEI ET AL.: "Direct comparison of two albumin-based paclitaxel-loaded nanoparticle formulations: Is the crosslinked version more advantageous?", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 468, no. l, April 2014 (2014-04-01), pages 15 - 25, XP029029801, DOI: 10.1016/j.ijpharm.2014.04.010
See also references of EP 3164114A4
See also references of EP 3164114A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (Scitech PlaceNo.22, Jian Guo Men Wai Ave. Chao Yang District, Beijing 4, CN)
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